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Schizophrenic disorders. The development of immunological concepts and therapy in psychiatry


Himmerich, H and Sorge, S and Kirkby, KC and Steinberg, H, Schizophrenic disorders. The development of immunological concepts and therapy in psychiatry, Nervenarzt, 83, (1) pp. 7-15. ISSN 0028-2804 (2012) [Refereed Article]

Copyright Statement

Copyright 2012 Springer-Verlag

DOI: doi:10.1007/s00115-010-3205-3


Immunological changes reported in patients with schizophrenia may play an aetiological role in these disorders. Further, immunomodulatory medications can influence the symptoms of psychiatric disorders. Antipsychotic agents such as clozapine may act therapeutically through the modulation of the immune system and also lead to side effects in that domain.Both the understanding and factual foundations of immunological concepts and immunological therapies of schizophrenic disorders have changed throughout the history of medicine. These are important considerations in psychiatry where diagnostic, nosological and therapeutic complexity is the norm. The article exemplarily presents publications of the psychiatrists such as Julius Wagner von Jauregg, Lewis Campbell Bruce and Friedrich Ostmann as well as neuropathologist Hermann Lehmann-Facius and haematologist William Dameshek.

Item Details

Item Type:Refereed Article
Research Division:Health Sciences
Research Group:Health services and systems
Research Field:Mental health services
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Mental health
UTAS Author:Kirkby, KC (Professor Kenneth Kirkby)
ID Code:82048
Year Published:2012
Web of Science® Times Cited:9
Deposited By:Medicine
Deposited On:2013-01-15
Last Modified:2017-11-06

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