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Acute elevation of lipids does not alter exercise hemodynamics in healthy men: a randomized controlled study


Sharman, JE and Holland, DJ and Leano, R and Kostner, KM, Acute elevation of lipids does not alter exercise hemodynamics in healthy men: a randomized controlled study, Atherosclerosis, 226, (1) pp. 234-237. ISSN 0021-9150 (2013) [Refereed Article]


Copyright Statement

Copyright 2012 Published by Elsevier Ireland Ltd.

DOI: doi:10.1016/j.atherosclerosis.2012.10.047


OBJECTIVE: Exaggerated exercise blood pressure (BP) predicts mortality. Some studies suggest this could be explained by chronic hyperlipidemia, but whether acute-hyperlipidemia effects exercise BP has never been tested, and was the aim of this study. METHODS: Intravenous infusion of saline (control) and Intralipid were administered over 60 min in 15 healthy men by double-blind, randomized, cross-over design. Brachial and central BP (including, pulse pressure, augmentation pressure and augmentation index), cardiac output and systemic vascular resistance were recorded at rest and during exercise. RESULTS: Compared with control, Intralipid caused significant increases in serum triglycerides, very low density lipoproteins and free fatty acids (p < 0.001 for all). However, there was no significant difference for any exercise hemodynamic variable (p > 0.05 for all). CONCLUSION: Acute-hyperlipidemia does not significantly change exercise hemodynamics in healthy males. Therefore, the association between raised lipids and increased exercise BP is likely due to the chronic effects of hyperlipidemia.

Item Details

Item Type:Refereed Article
Keywords:Cholesterol, Hemodynamics, Aorta, Physical activity, Hypertension
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiovascular medicine and haematology not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Sharman, JE (Professor James Sharman)
ID Code:81694
Year Published:2013
Web of Science® Times Cited:1
Deposited By:Menzies Institute for Medical Research
Deposited On:2012-12-21
Last Modified:2016-06-27
Downloads:89 View Download Statistics

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