O'Neil, A and Sanna, L and Redlich, C and Sanderson, K and Jacka, F and Williams, LJ and Pasco, JA and Berk, M, The impact of statins on psychological wellbeing: a systematic review and meta-analysis, BMC Medicine, 10 Article 154. ISSN 1741-7015 (2012) [Refereed Article]
Licensed under Creative Commons Attribution 2.0 Generic (CC BY 2.0) http://creativecommons.org/licenses/by/2.0/
Background: Cholesterol-lowering medications such as statins have anti-inflammatory and antioxidant properties, which may be beneficial for treating depression and improving mood. However, evidence regarding their effects remains inconsistent, with some studies reporting links to mood disturbances. We aimed to conduct a metaanalysis to determine the impact of statins on psychological wellbeing of individuals with or without hypercholesterolemia.
Methods: Articles were identified using medical, health, psychiatric and social science databases, evaluated for quality, and data were synthesized and analyzed in RevMan-5 software using a random effects model.
Results: The 7 randomized controlled trials included in the analysis represented 2,105 participants. A test for overall effect demonstrated no statistically significant differences in psychological wellbeing between participants receiving statins or a placebo (standardized mean difference (SMD) = -0.08, 95% CI -0.29 to 0.12; P = 0.42). Sensitivity analyses were conducted to separately analyze depression (n = 5) and mood (n = 2) outcomes; statins were associated with statistically significant improvements in mood scores (SMD = -0.43, 95% CI -0.61 to -0.24).
Conclusions: Our findings refute evidence of negative effects of statins on psychological outcomes, providing some support for mood-related benefits. Future studies could examine the effects of statins in depressed populations.
|Item Type:||Refereed Article|
|Keywords:||anti-inflammatory, cytokines, depression, hypercholesterolemia, mood, oxidative, statins|
|Research Division:||Medical and Health Sciences|
|Research Group:||Public Health and Health Services|
|Research Field:||Mental Health|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Cardiovascular System and Diseases|
|Author:||Sanderson, K (Associate Professor Kristy Sanderson)|
|Funding Support:||Australian Research Council (FT0991524)|
|Web of Science® Times Cited:||39|
|Deposited By:||Menzies Institute for Medical Research|
|Downloads:||221 View Download Statistics|
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