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Emerging Putative Biomarkers: The Role of Alpha 2 and 6 Integrins in Susceptibility, Treatment and Prognosis
Citation
Marthick, JR and Dickinson, JL, Emerging Putative Biomarkers: The Role of Alpha 2 and 6 Integrins in Susceptibility, Treatment and Prognosis, Prostate Cancer, 2012 Article 298732. ISSN 2090-3111 (2012) [Refereed Article]
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Copyright Statement
Licensed under Creative Commons Attribution 3.0 Unported (CC BY 3.0) http://creativecommons.org/licenses/by/3.0/
Abstract
The genetic architecture underpinning prostate cancer is complex, polygenic and despite recent significant advances many questions remain. Advances in genetic technologies have greatly improved our ability to identify genetic variants associated with complex disease including prostate cancer. Genome-wide association studies (GWASs) and microarray gene expression studies have identified genetic associations with prostate cancer susceptibility and tumour development. The integrins feature prominently in both studies examining the underlying genetic susceptibility and mechanisms driving prostate tumour development. Integrins are cell adhesion molecules involved in extracellular and intracellular signalling and are imperative for tumour development, migration, and angiogenesis. Although several integrins have been implicated in tumour development, the roles of integrin á(2) and integrin á(6) are the focus of this paper as evidence is now emerging that these integrins are implicit in prostate cancer susceptibility, cancer stem cell biology, angiogenesis, cell migration, and metastases to bone and represent potential biomarkers and therapeutic targets. There currently exists an urgent need to develop tools that differentiate indolent from aggressive prostate cancers and predict how patients will respond to treatment. This paper outlines the evidence supporting the use of &alpha2 and &alpha6 integrins in clinical applications for tailored patient treatment.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | biomarkers, prostate cancer, integrins |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Oncology and carcinogenesis |
| Research Field: | Cancer genetics |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Marthick, JR (Mr James Marthick) |
| UTAS Author: | Dickinson, JL (Professor Joanne Dickinson) |
| ID Code: | 81077 |
| Year Published: | 2012 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2012-11-22 |
| Last Modified: | 2018-02-08 |
| Downloads: | 293 View Download Statistics |
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