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The association between parity and knee cartilage in young women

Citation

Wei, S and Jones, G and Venn, A and Cicuttini, F and March, L and Otahal, P and Cross, M and Dalton, M and Dwyer, T and Ding, C, The association between parity and knee cartilage in young women, Rheumatology, 51, (11) pp. 2039-2045. ISSN 0080-2727 (2012) [Refereed Article]

Copyright Statement

Copyright 2012 The Author

DOI: doi:10.1093/rheumatology/kes201

Abstract

Objectives: There have been no reported studies of the association between parity and cartilage in young individuals. The aim of this study was to describe the association between parity, cartilage volume and cartilage defects in women aged 31-41 years.

Methods: Cross-sectional study of 144 women, mean age 36 years and BMI 25 kg/m2, who were participants in an established prospective study. Parity was assessed using a questionnaire. Knee (medial tibial, lateral tibial and patellar) cartilage volume, cartilage defects (grade 04 depending on the severity of cartilage thickness loss at tibial and patellar sites) and tibial bone area were assessed using T1-weighted fat-suppressed MRI.

Results: The prevalence of cartilage defects (grade ≥ 2) in this population was 13%. Parity was associated with a higher risk of cartilage defects at the patellar [prevalence ratio (PR) per birth 1.52, 95% CI 1.05, 2.21; PR parous vs nulliparous 1.93, 95% CI 0.66, 5.65], but not tibial sites, after adjustment for confounders including age, BMI, smoking, physical activity, knee injury and tibial bone area. This association between parity and patellar cartilage defects was stronger for those women who had three or more births (vs nulliparous, PR 5.27, 95% CI 1.39, 20.01). There were no significant associations between parity and cartilage volume.

Conclusion: Parity was associated with knee cartilage defects primarily at the patellar site in this sample of young women. This association was more apparent with increasing number of live births, suggesting a possible adverse effect of parity on knee cartilage.

Item Details

Item Type:Refereed Article
Keywords:parity, cartilage defects, cartilage volume, young women
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Wei, S (Mrs Shuying Wei)
Author:Jones, G (Professor Graeme Jones)
Author:Venn, A (Professor Alison Venn)
Author:Otahal, P (Mr Petr Otahal)
Author:Dalton, M (Ms Marita Dalton)
Author:Ding, C (Professor Chang-Hai Ding)
ID Code:80724
Year Published:2012
Web of Science® Times Cited:1
Deposited By:Menzies Institute for Medical Research
Deposited On:2012-11-08
Last Modified:2017-11-02
Downloads:0

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