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Ca2+/cAMP-sensitive covariation of IA and IH voltage dependences tunes rebound firing in dopaminergic neurons

journal contribution
posted on 2023-05-17, 13:55 authored by Amendola, J, Adele WoodhouseAdele Woodhouse, Martin-Eauclaire, M-F, Goaillard, J-M
The level of expression of ion channels has been demonstrated to vary over a threefold to fourfold range from neuron to neuron, although the expression of distinct channels may be strongly correlated in the same neurons. We demonstrate that variability and covariation also apply to the biophysical properties of ion channels. We show that, in rat substantia nigra pars compacta dopaminergic neurons, the voltage dependences of the A-type (I(A)) and H-type (I(H)) currents exhibit a high degree of cell-to-cell variability, although they are strongly correlated in these cells. Our data also demonstrate that this cell-to-cell covariability of voltage dependences is sensitive to cytosolic cAMP and calcium levels. Finally, using dynamic clamp, we demonstrate that covarying I(A) and I(H) voltage dependences increases the dynamic range of rebound firing while covarying their amplitudes has a homeostatic effect on rebound firing. We propose that the covariation of voltage dependences of ion channels represents a flexible and energy-efficient way of tuning firing in neurons.

History

Publication title

Journal of Neuroscience

Volume

32

Issue

6

Pagination

2166-2181

ISSN

0270-6474

Department/School

Tasmanian School of Medicine

Publisher

Society for Neuroscience

Place of publication

1121 14th St, NW, Washington DC, USA

Rights statement

Copyright 2012 the authors

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the biological sciences

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