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Ca2+/cAMP-sensitive covariation of IA and IH voltage dependences tunes rebound firing in dopaminergic neurons

Citation

Amendola, J and Woodhouse, A and Martin-Eauclaire, M-F and Goaillard, J-M, Ca2+/cAMP-sensitive covariation of IA and IH voltage dependences tunes rebound firing in dopaminergic neurons, Journal of Neuroscience, 32, (6) pp. 2166-2181. ISSN 0270-6474 (2012) [Refereed Article]


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Copyright Statement

Copyright 2012 the authors

DOI: doi:10.1523/JNEUROSCI.5297-11.2012

Abstract

The level of expression of ion channels has been demonstrated to vary over a threefold to fourfold range from neuron to neuron, although the expression of distinct channels may be strongly correlated in the same neurons. We demonstrate that variability and covariation also apply to the biophysical properties of ion channels. We show that, in rat substantia nigra pars compacta dopaminergic neurons, the voltage dependences of the A-type (I(A)) and H-type (I(H)) currents exhibit a high degree of cell-to-cell variability, although they are strongly correlated in these cells. Our data also demonstrate that this cell-to-cell covariability of voltage dependences is sensitive to cytosolic cAMP and calcium levels. Finally, using dynamic clamp, we demonstrate that covarying I(A) and I(H) voltage dependences increases the dynamic range of rebound firing while covarying their amplitudes has a homeostatic effect on rebound firing. We propose that the covariation of voltage dependences of ion channels represents a flexible and energy-efficient way of tuning firing in neurons.

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Physiology
Research Field:Animal Physiology - Biophysics
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Biological Sciences
Author:Woodhouse, A (Dr Adele Woodhouse)
ID Code:80387
Year Published:2012
Web of Science® Times Cited:43
Deposited By:Medicine (Discipline)
Deposited On:2012-10-31
Last Modified:2013-05-06
Downloads:0

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