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Reduced benzimidazo[2,1-a]isoquinolines. Synthesis and cytotoxicity studies


Deady, LW and Rodemann, T, Reduced benzimidazo[2,1-a]isoquinolines. Synthesis and cytotoxicity studies, Australian Journal of Chemistry: An International Journal for Chemical Science, 54, (8) pp. 529-534. ISSN 0004-9425 (2001) [Refereed Article]

DOI: doi:10.1071/CH01114


6-Butyl-5,6-dihydrobenzimidazo[2,1-a]isoquinoline, 3,9- and 3,10-dimethoxy, and 3,9- and 3,10-dihydroxy analogs, and their quaternary salts were prepd. by a multistep route. Cytotoxicity against 55 cancer cell lines were measured in the National Cancer Institute screen. The quaternary salts of the dimethoxy derivs. were clearly the most active overall, with a mean graph midpoint (MGM) value of 2 μm. The activity of the title compd. was compared to that of dihydroxyindolo[2,1-a]isoquinoline-12-carboxaldehyde derivs.

Item Details

Item Type:Refereed Article
Research Division:Chemical Sciences
Research Group:Medicinal and biomolecular chemistry
Research Field:Medicinal and biomolecular chemistry not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Rodemann, T (Dr Thomas Rodemann)
ID Code:80380
Year Published:2001
Web of Science® Times Cited:33
Deposited By:Central Science Laboratory
Deposited On:2012-10-30
Last Modified:2012-10-30

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