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Reduced benzimidazo[2,1-a]isoquinolines. Synthesis and cytotoxicity studies
journal contribution
posted on 2023-05-17, 13:55 authored by Deady, LW, Thomas RodemannThomas Rodemann6-Butyl-5,6-dihydrobenzimidazo[2,1-a]isoquinoline, 3,9- and 3,10-dimethoxy, and 3,9- and 3,10-dihydroxy analogs, and their quaternary salts were prepd. by a multistep route. Cytotoxicity against 55 cancer cell lines were measured in the National Cancer Institute screen. The quaternary salts of the dimethoxy derivs. were clearly the most active overall, with a mean graph midpoint (MGM) value of 2 μm. The activity of the title compd. was compared to that of dihydroxyindolo[2,1-a]isoquinoline-12-carboxaldehyde derivs.
History
Publication title
Australian Journal of Chemistry: An International Journal for Chemical ScienceVolume
54Issue
8Pagination
529-534ISSN
0004-9425Publisher
C S I R O PublishingPlace of publication
150 Oxford St, Po Box 1139, Collingwood, Australia, Victoria, 3066Repository Status
- Restricted