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Oral administration of glucose promotes intracellular partitioning of fatty acid toward storage in white but not in red muscle
Citation
Fosgerau, K and Fledelius, C and Fledelius, KE and Kristensen, B and Daugaard, JR and Iglesias, MA and Kraegen, EW and Furler, SM, Oral administration of glucose promotes intracellular partitioning of fatty acid toward storage in white but not in red muscle, Journal of Endocrinology, 190, (3) pp. 651-8. ISSN 0022-0795 (2006) [Refereed Article]
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Copyright Statement
Copyright 2006 Society for Endocrinology
Abstract
Lipid accumulation in non-adipose tissues is strongly associated with the metabolic syndrome, possibly due to aberrant partitioning of intracellular fatty acids between storage and oxidation. In the present study, we administered the non-metabolizable fatty acid analog [9,10-(3)H]-(R)-2-bromopalmitate, and authentic (14)C-palmitate to conscious rats, in order to directly examine the initial intracellular fate of fatty acids in a range of insulin-sensitive tissues, including white and red muscles, liver, white adipose tissue, and heart. Rats were studied after administration of an oral glucose load to examine the effect of physiological elevation of glucose and insulin. The tracer results showed that glucose administration partitioned fatty acid toward storage in white muscle (storage:uptake ratios, vehicle vs glucose; 0.64 +/- 0.02 vs 0.92 +/- 0.09, P < 0.05), and in liver (0.66 +/- 0.07 vs 0.98 +/- 0.04, P < 0.05), but not in red muscle (1.18 +/- 0.07 vs 1.36 +/- 0.11, P = not significant). These results demonstrate the physiological relevance of the so-called 'reverse' Randle cycle, but surprisingly show that it may be more important in white rather than oxidative red muscle.
Item Details
Item Type: | Refereed Article |
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Research Division: | Biomedical and Clinical Sciences |
Research Group: | Medical biochemistry and metabolomics |
Research Field: | Metabolic medicine |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Iglesias, MA (Dr Miguel Iglesias) |
ID Code: | 80256 |
Year Published: | 2006 |
Web of Science® Times Cited: | 1 |
Deposited By: | Health Sciences A |
Deposited On: | 2012-10-25 |
Last Modified: | 2012-11-21 |
Downloads: | 0 |
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