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Deep brain stimulation and postoperative suicidality among treatment resistant depression patients: should eligibility protocols exclude patients with a history of suicide attempts and anger/impulsivity?

Citation

Gilbert, F, Deep brain stimulation and postoperative suicidality among treatment resistant depression patients: should eligibility protocols exclude patients with a history of suicide attempts and anger/impulsivity?, AJOB Neuroscience Journal, 4, (1) pp. 28-35. ISSN 2150-7740 (2013) [Refereed Article]

Copyright Statement

Copyright 2012 Taylor and Francis.

Official URL: http://www.tandfonline.com/toc/uabn20/current

DOI: doi:10.1080/21507740.2012.740143

Abstract

Recently, there has been a surge of interest in using Deep Brain Stimulation (DBS) to treat patients suffering from Treatment Resistance Depression (TRD). While DBS has been regarded as an efficient and safe treatment for many conditions over the last 20 years, and although DBS research trials involving TRD patients show encouraging evidence of remission, recent DBS TRD follow-up studies have reported significant rates of postoperative suicidal ideation, as well as suicide attempts and deaths. Given the vulnerable nature of TRD patients with respect to suicide, if the postoperative DBS adjustment process contributes to an increased risk of suicidality among them, then there is a pressing need to investigate this problem. Based on current clinical trial follow-up data, does the suicidality risk-versusremission benefit ratio favor the use of DBS in TRD patients? The purpose of this article is to examine whether adjusting enrollment criteria, such as excluding TRD patients with a history of suicide attempts or anger/impulsivity, could diminish DBS trial research suicidality, given the absence of uniformity in DBS trial eligibility protocols.

Item Details

Item Type:Refereed Article
Keywords:anger, impulsive behaviour, deep brain stimulation, suicidal attempts, suicidal death, suicidality, treatment-resistant-depression, depression, human subjects, neuroethics, research, neurobiology
Research Division:Philosophy and Religious Studies
Research Group:Applied Ethics
Research Field:Ethical Use of New Technology (e.g. Nanotechnology, Biotechnology)
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in Philosophy and Religious Studies
Author:Gilbert, F (Dr Frederic Gilbert)
ID Code:80095
Year Published:2013
Deposited By:Humanities
Deposited On:2012-10-22
Last Modified:2015-11-25
Downloads:0

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