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The association between objectively measured physical activity and knee structural change using MRI

Citation

Dore, DA and Winzenberg, TM and Ding, C and Otahal, P and Pelletier, JP and Martel-Pelletier, J and Cicuttini, FM and Jones, G, The association between objectively measured physical activity and knee structural change using MRI, Annals of the Rheumatic Diseases, 72, (7) pp. 1170-1175. ISSN 0003-4967 (2013) [Refereed Article]

Copyright Statement

Copyright 2012 the Authors

DOI: doi:10.1136/annrheumdis-2012-201691

Abstract

Objectives: This study describes the longitudinal association between objectively assessed physical activity (PA) and knee structural change measured using MRI.

Methods: 405 community-dwelling adults aged 51-81 years were measured at baseline and approximately 2.7 years later. MRI of the right knee at baseline and follow-up was performed to evaluate bone marrow lesions (BMLs), meniscal pathology, cartilage defects, and cartilage volume. PA was assessed at baseline by pedometer (steps/day).

Results: Doing ≥10 000 steps/day was associated with BML increases (RR 1.97, 95% CI 1.19 to 3.27, p=0.009). Participants doing ≥10 000 steps/day had a 1.52 times (95% CI 1.05 to 2.20, p=0.027) greater risk of increasing meniscal pathology score, which increased to 2.49 (95% CI 1.05 to 3.93, p=0.002) in those with adverse meniscal pathology at baseline. Doing 10 000 steps/day was associated with a greater risk of increasing cartilage defect score in those with prevalent BMLs at baseline (RR 1.36, 95% CI 1.03 to 1.69, p=0.013). Steps/day was protective against volume loss in those with more baseline cartilage volume but led to increased cartilage loss in those with less baseline cartilage volume. (p=0.046 for interaction).

Conclusions: PA was deleteriously associated with knee structural change, especially in those with pre-existing knee structural abnormalities. This suggests individuals with knee abnormalities should avoid doing ≥10 000 steps/day. Alternatives to weight-bearing activity may be needed in order to maintain PA levels required for other aspects of health.

Item Details

Item Type:Refereed Article
Keywords:physical activity, osteoarthritis, magnetic resonance imaging
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Dore, DA (Dr Dawn Aitken)
Author:Winzenberg, TM (Professor Tania Winzenberg)
Author:Ding, C (Professor Chang-Hai Ding)
Author:Otahal, P (Mr Petr Otahal)
Author:Jones, G (Professor Graeme Jones)
ID Code:80039
Year Published:2013 (online first 2012)
Deposited By:Menzies Institute for Medical Research
Deposited On:2012-10-18
Last Modified:2014-09-09
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