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Temperature-programmable low thermal mass silicon micromachined gas chromatography and differential mobility detection for the fast analysis of trace level of ethylene oxide in medical work place atmospheres

Citation

Luong, J and Gras, R and Cortes, HJ and Shellie, RA, Temperature-programmable low thermal mass silicon micromachined gas chromatography and differential mobility detection for the fast analysis of trace level of ethylene oxide in medical work place atmospheres, Journal of Chromatography A, 1261 pp. 136-141. ISSN 0021-9673 (2012) [Refereed Article]

Copyright Statement

Copyright 2012 Elsevier B.V.

DOI: doi:10.1016/j.chroma.2012.06.087

Abstract

A portable, fast gas chromatographic method for the direct measurement of part-per-billion level of ethylene oxide in medical work place atmospheres is introduced. Ethylene oxide is a chemical of significance in life science for its critical role as a highly effective sterilizing agent for heat sensitive surgical instruments. However, ethylene oxide is highly flammable, a suspected human carcinogen, is mutagenic, and henceforth, requires close monitoring. The approach incorporates a temperature-programmable silicon micromachined gas chromatograph for the fast separation of ethylene oxide from airborne organic interferences. The separation approach is hyphenated to a micromachined differential mobility detector, improving targeted analyte detection, and enhancing the overall selectivity obtained. A complete analysis can be conducted in less than 60 s. Further, ethylene oxide in the matrix mentioned can be measured directly with low possibility of false positives and without the need for any sample pre-treatment, such as pre-concentration or derivatization. A relative precision of less than 5% RSD (n = 20) over a range from 5 parts per billion (v/v) to 500 parts per billion (v/v) was obtained.

Item Details

Item Type:Refereed Article
Keywords:ethylene oxide, gas chromatography, portable, differential mobility detection, air monitoring
Research Division:Chemical Sciences
Research Group:Analytical Chemistry
Research Field:Separation Science
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
Author:Luong, J (Mr Jim Luong)
Author:Cortes, HJ (Dr Hernan Cortes)
Author:Shellie, RA (Associate Professor Robert Shellie)
ID Code:79768
Year Published:2012
Web of Science® Times Cited:1
Deposited By:Austn Centre for Research in Separation Science
Deposited On:2012-10-02
Last Modified:2013-04-22
Downloads:0

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