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Evaluation of the Innovance D-Dimer assay for the diagnosis of disseminated intravascular coagulopathy in different clinical settings

Citation

Khalafallah, A and Jarvis, C and Morse, M and Al-Barazan, A-M and Stewart, P and Bates, G and Hayes, R and Robertson, I and Seaton, D and Brain, T, Evaluation of the Innovance D-Dimer assay for the diagnosis of disseminated intravascular coagulopathy in different clinical settings, Clinical and Applied Thrombosis - Hemostasis, 20, (1) pp. 91-97 . ISSN 1076-0296 (2014) [Refereed Article]

Copyright Statement

Copyright 2012 Sage Publications

DOI: doi:10.1177/1076029612454936

Abstract

Disseminated intravascular coagulopathy (DIC) is a serious disease with fatal consequences. We prospectively analyzed Innovance d-dimer immunoturbidimetric assay in 68 patients diagnosed with DIC on the background of malignancy (22), severe infection (20), or multitrauma (26) at a single institution between January 2010 and January 2011. Median age was 61 years (range 20-89). All patients were assessed according to the International Society of Thrombosis and Haemostasis (ISTH) DIC score. Applying a threshold of Innovance D-dimer of 10 mg/L fibrinogen equivalent unit (normal <0.5) was correlated with the highest sensitivity in malignancy (86%) and trauma/surgery (80%) compared to 54% in infection. The specificity remained high at 97% in infection, 81% in trauma and 77% in malignancy with a negative predictive value of 97% in trauma and malignancy, and 88% in infection. Our data suggest that Innovance D-dimer is a useful and simple tool that enhances the ISTH DIC diagnostic criteria. Further studies to confirm these findings are warranted.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Haematology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Blood Disorders
Author:Khalafallah, A (Professor Alhossain Khalafallah)
Author:Morse, M (Mr Michael Morse)
Author:Al-Barazan, A-M (Dr Abdul Majeed)
Author:Robertson, I (Dr Iain Robertson)
ID Code:79550
Year Published:2014 (online first 2012)
Web of Science® Times Cited:2
Deposited By:Research Division
Deposited On:2012-09-19
Last Modified:2017-01-18
Downloads:0

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