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Direct measurement of part-per-billion levels of dimethyl sulfoxide in water by gas chromatography with stacked injection and chemiluminescence detection

Citation

Luong, J and Gras, R and Shellie, RA and Cortes, HJ, Direct measurement of part-per-billion levels of dimethyl sulfoxide in water by gas chromatography with stacked injection and chemiluminescence detection, Journal of Separation Science, 35, (12) pp. 1486-1493. ISSN 1615-9306 (2012) [Refereed Article]

Copyright Statement

Copyright 2012 WILEY-VCH Verlag.

DOI: doi:10.1002/jssc.201101087

Abstract

Dimethyl sulfoxide (DMSO) is a chemical of industrial significance with many important applications. DMSO is used as an industrial solvent, in drug delivery and healthcare applications, among others. Analysis of DMSO in water typically involves extensive sample preparation, enrichment, and derivatization to improve solute detectability. A novel gas chromatographic procedure has been developed for the direct measurement of trace levels of DMSO in an aqueousmatrix, such as potable water. The technology utilizes stacked injection techniques for in-column solute enrichment, a precolumn to enhance solute focusing effects, and sulfur chemiluminescence detection for matrix suppression and sensitivity. A detection limit of 2 parts per billion (ppb) (v/v) of DMSO in water was attained. Relative precision of less than 7% at the concentration of 10 ppb (v/v) of DMSO was demonstrated. A correlation coefficient of 0.9988 was obtained over a range of 2 ppb (v/v) to 100 ppb (v/v). No detectable carry-over was found at the 5 ppb (v/v) level whereas less than 4% carry-over was observed at the 100 ppb (v/v) level. Various sample storage media including glass, polyethylene, and polycarbonate were also studied to minimize solute loss. Recoveries greater than 84% were achieved with all storage media tested. The method was found to be reliable and simple to implement.

Item Details

Item Type:Refereed Article
Keywords:chemiluminescence detection, dimethyl sulfoxide, potable water, stacked injection
Research Division:Chemical Sciences
Research Group:Analytical Chemistry
Research Field:Separation Science
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
Author:Luong, J (Mr Jim Luong)
Author:Shellie, RA (Associate Professor Robert Shellie)
Author:Cortes, HJ (Dr Hernan Cortes)
ID Code:79513
Year Published:2012
Web of Science® Times Cited:1
Deposited By:Austn Centre for Research in Separation Science
Deposited On:2012-09-18
Last Modified:2013-04-22
Downloads:0

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