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Multi-dimensional gas chromatography with a planar microfluidic device for the characterization of volatile oxygenated organic compounds


Luong, J and Gras, R and Cortes, H and Shellie, RA, Multi-dimensional gas chromatography with a planar microfluidic device for the characterization of volatile oxygenated organic compounds, Journal of Chromatography A, 1255 pp. 216-220. ISSN 0021-9673 (2012) [Refereed Article]

Copyright Statement

Copyright 2012 Elsevier B.V.

DOI: doi:10.1016/j.chroma.2012.01.073


Oxygenated compounds like methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, acetaldehyde, crotonaldehyde, ethylene oxide, tetrahydrofuran, 1,4-dioxane, 1,3-dioxolane, and 2-chloromethyl-1,3-dioxolane are commonly encountered in industrial manufacturing processes. Despite the availability of a variety of column stationary phases for chromatographic separation, it is difficult to separate these solutes from their respective matrices using single dimension gas chromatography. Implemented with a planar microfluidic device, conventional two-dimensional gas chromatography and the employment of chromatographic columns using dissimilar separation mechanisms like that of a selective wall-coated open tubular column and an ionic sorbent column have been successfully applied to resolve twelve industrially significant volatile oxygenated compounds in both gas and aqueous matrices. A Large Volume Gas Injection System (LVGIS) was also employed for sample introduction to enhance system automation and precision. By successfully integrating these concepts, in addition to having the capability to separate all twelve components in one single analysis, features associated with multi-dimensional gas chromatography like dual retention time capability, and the ability to quarantine undesired chromatographic contaminants or matrix components in the first dimension column to enhance overall system cleanliness were realized. With this technique, a complete separation for all the compounds mentioned can be carried out in less than 15 min. The compounds cited can be analyzed over a range of 250 ppm (v/v) to 100 ppm (v/v) with a relative standard deviation of less than 5% (n = 20) with high degree of reliability.

Item Details

Item Type:Refereed Article
Keywords:MDGC, volatile oxygenated compounds, large volume gas injection system (LVGIS)
Research Division:Chemical Sciences
Research Group:Analytical chemistry
Research Field:Separation science
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the chemical sciences
UTAS Author:Luong, J (Mr Jim Luong)
UTAS Author:Cortes, H (Dr Hernan Cortes)
UTAS Author:Shellie, RA (Associate Professor Robert Shellie)
ID Code:79511
Year Published:2012
Web of Science® Times Cited:11
Deposited By:Austn Centre for Research in Separation Science
Deposited On:2012-09-18
Last Modified:2013-04-22

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