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Multi-dimensional gas chromatography with a planar microfluidic device for the characterization of volatile oxygenated organic compounds

journal contribution
posted on 2023-05-17, 13:13 authored by Luong, J, Gras, R, Cortes, H, Robert ShellieRobert Shellie
Oxygenated compounds like methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, acetaldehyde, crotonaldehyde, ethylene oxide, tetrahydrofuran, 1,4-dioxane, 1,3-dioxolane, and 2-chloromethyl-1,3-dioxolane are commonly encountered in industrial manufacturing processes. Despite the availability of a variety of column stationary phases for chromatographic separation, it is difficult to separate these solutes from their respective matrices using single dimension gas chromatography. Implemented with a planar microfluidic device, conventional two-dimensional gas chromatography and the employment of chromatographic columns using dissimilar separation mechanisms like that of a selective wall-coated open tubular column and an ionic sorbent column have been successfully applied to resolve twelve industrially significant volatile oxygenated compounds in both gas and aqueous matrices. A Large Volume Gas Injection System (LVGIS) was also employed for sample introduction to enhance system automation and precision. By successfully integrating these concepts, in addition to having the capability to separate all twelve components in one single analysis, features associated with multi-dimensional gas chromatography like dual retention time capability, and the ability to quarantine undesired chromatographic contaminants or matrix components in the first dimension column to enhance overall system cleanliness were realized. With this technique, a complete separation for all the compounds mentioned can be carried out in less than 15 min. The compounds cited can be analyzed over a range of 250 ppm (v/v) to 100 ppm (v/v) with a relative standard deviation of less than 5% (n = 20) with high degree of reliability.

History

Publication title

Journal of Chromatography A

Volume

1255

Pagination

216-220

ISSN

0021-9673

Department/School

School of Natural Sciences

Publisher

Elsevier

Place of publication

Amsterdam

Rights statement

Copyright 2012 Elsevier B.V.

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the chemical sciences

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