University of Tasmania
Browse

File(s) under permanent embargo

Insulin-induced microvascular recruitment in skin and muscle are related and both are associated with whole-body glucose uptake

journal contribution
posted on 2023-05-17, 13:12 authored by Meijer, RI, De Boer, MP, Groen, MR, Eringa, EC, Stephen RattiganStephen Rattigan, Barrett, EJ, Smulders, YM, Serne, EH

Objective:  Insulin-induced capillary recruitment is considered a determinant of insulin-mediated glucose uptake. Insulin action on the microvasculature has been assessed in skin; however, there is concern as to whether the vascular responses observed in skin reflect those in the muscle. We hypothesized that insulin-induced capillary recruitment in skin would correlate with microvascular recruitment in muscle in a group of subjects displaying a wide variation in insulin sensitivity.

Methods:  Capillary recruitment in skin was assessed using capillary videomicroscopy, and skeletal muscle microvascular recruitment (i.e., increase in MBV) was studied using CEU in healthy volunteers (n = 18, mean age: 30.6 ± 11.1 years). Both microvascular measurements were performed during saline infusion, and during a hyperinsulinemic euglycemic clamp.

Results:  During hyperinsulinemia, capillary recruitment in skin was augmented from 58.1 ± 18.2% to 81.0 ± 23.9% (p < 0.0001). Hyperinsulinemia increased MBV in muscle from 7.00 (2.66–17.67) to 10.06 (2.70–41.81) units (p = 0.003). Insulin’s vascular effect in skin and muscle was correlated (r = 0.57). Insulin’s microvascular effects in skin and muscle showed comparable strong correlations with insulin-mediated glucose uptake (r = 0.73 and 0.68, respectively).

Conclusions:  Insulin-augmented capillary recruitment in skin parallels insulin-mediated microvascular recruitment in muscle and both are related to insulin-mediated glucose uptake.

Funding

National Health & Medical Research Council

History

Publication title

Microcirculation

Volume

19

Issue

6

Pagination

494-500

ISSN

1073-9688

Department/School

Menzies Institute for Medical Research

Publisher

Nature Publishing Group

Place of publication

345 Park Ave South, New York, USA, Ny, 10010-1707

Rights statement

Copyright 2012 John Wiley & Sons Ltd

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

Usage metrics

    University Of Tasmania

    Categories

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC