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Insulin-induced microvascular recruitment in skin and muscle are related and both are associated with whole-body glucose uptake
Meijer, RI and De Boer, MP and Groen, MR and Eringa, EC and Rattigan, S and Barrett, EJ and Smulders, YM and Serne, EH, Insulin-induced microvascular recruitment in skin and muscle are related and both are associated with whole-body glucose uptake, Microcirculation, 19, (6) pp. 494-500. ISSN 1073-9688 (2012) [Refereed Article]
Copyright 2012 John Wiley & Sons Ltd
Objective: Insulin-induced capillary recruitment is considered a determinant of insulin-mediated glucose uptake. Insulin action on the microvasculature has been assessed in skin; however, there is concern as to whether the vascular responses observed in skin reflect those in the muscle. We hypothesized that insulin-induced capillary recruitment in skin would correlate with microvascular recruitment in muscle in a group of subjects displaying a wide variation in insulin sensitivity.
Methods: Capillary recruitment in skin was assessed using capillary videomicroscopy, and skeletal muscle microvascular recruitment (i.e., increase in MBV) was studied using CEU in healthy volunteers (n = 18, mean age: 30.6 ± 11.1 years). Both microvascular measurements were performed during saline infusion, and during a hyperinsulinemic euglycemic clamp.
Results: During hyperinsulinemia, capillary recruitment in skin was augmented from 58.1 ± 18.2% to 81.0 ± 23.9% (p < 0.0001). Hyperinsulinemia increased MBV in muscle from 7.00 (2.66–17.67) to 10.06 (2.70–41.81) units (p = 0.003). Insulin’s vascular effect in skin and muscle was correlated (r = 0.57). Insulin’s microvascular effects in skin and muscle showed comparable strong correlations with insulin-mediated glucose uptake (r = 0.73 and 0.68, respectively).
Conclusions: Insulin-augmented capillary recruitment in skin parallels insulin-mediated microvascular recruitment in muscle and both are related to insulin-mediated glucose uptake.
|Item Type:||Refereed Article|
|Keywords:||microcirculation, contrast-enhanced ultrasonography, capillary videomicroscopy, insulin-induced microvascular recruitment, insulin sensitivity|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Clinical sciences|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Rattigan, S (Professor Stephen Rattigan)|
|Funding Support:||National Health and Medical Research Council (490034)|
|Web of Science® Times Cited:||62|
|Deposited By:||Menzies Institute for Medical Research|
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