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Skeletal muscle nitric oxide signaling and exercise: a focus on glucose metabolism


McConell, GK and Rattigan, S and Lee-Young, RS and Wadley, GD and Merry, TL, Skeletal muscle nitric oxide signaling and exercise: a focus on glucose metabolism, American Journal of Physiology: Endocrinology and Metabolism, 303, (3) pp. E301-E307. ISSN 0193-1849 (2012) [Refereed Article]

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Copyright 2012 the American Physiological Society

DOI: doi:10.1152/ajpendo.00667.2011


Nitric oxide (NO) is an important vasodilator and regulator in the cardiovascular system, and this link was the subject of a Nobel prize in 1998. However, NO also plays many other regulatory roles, including thrombosis, immune function, neural activity, and gastrointestinal function. Low concentrations of NO are thought to have important signaling effects. In contrast, high concentrations of NO can interact with reactive oxygen species, causing damage to cells and cellular components. A less-recognized site of NO production is within skeletal muscle, where small increases are thought to have beneficial effects such as regulating glucose uptake and possibly blood flow, but higher levels of production are thought to lead to deleterious effects such as an association with insulin resistance. This review will discuss the role of NO in skeletal muscle during and following exercise, including in mitochondrial biogenesis, muscle efficiency, and blood flow with a particular focus on its potential role in regulating skeletal muscle glucose uptake during exercise.

Item Details

Item Type:Refereed Article
Keywords:nitric oxide, glucose uptake, blood flow, oxygen consumption, efficiency, 5'-adenosine monophosphate-activated protein kinase, contraction, reactive oxygen species, mitochondrial biogenesis, metabolism
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Rattigan, S (Professor Stephen Rattigan)
ID Code:79500
Year Published:2012
Funding Support:National Health and Medical Research Council (490034)
Web of Science® Times Cited:60
Deposited By:Menzies Institute for Medical Research
Deposited On:2012-09-17
Last Modified:2013-04-17
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