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ATM signaling and genomic stability in response to DNA damage
journal contribution
posted on 2023-05-22, 23:37 authored by Lavin, MF, Birrell, G, Chen, P, Kozlov, S, Scott, S, Nuri GuvenNuri GuvenDNA double strand breaks represent the most threatening lesion to the integrity of the genome in cells exposed to ionizing radiation and radiomimetic chemicals. Those breaks are recognized, signaled to cell cycle checkpoints and repaired by protein complexes. The product of the gene (ATM) mutated in the human genetic disorder ataxia-telangiectasia (A-T) plays a central role in the recognition and signaling of DNA damage. ATM is one of an ever growing number of proteins which when mutated compromise the stability of the genome and predispose to tumour development. Mechanisms for recognising double strand breaks in DNA, maintaining genome stability and minimizing risk of cancer are discussed.
History
Publication title
Mutation Research - D N AgingVolume
569Issue
1-2Pagination
123-32ISSN
0921-8734Department/School
School of Pharmacy and PharmacologyPublisher
Elsevier BVPlace of publication
NetherlandsRights statement
Copyright 2004 ElsevierRepository Status
- Restricted