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Defective responses to DNA single- and double-strand breaks in spinocerebellar ataxia

Citation

Lavin, MF and Gueven, N and Grattan-Smith, P, Defective responses to DNA single- and double-strand breaks in spinocerebellar ataxia, DNA Repair, 7 pp. 1061-1076. ISSN 1568-7864 (2008) [Substantial Review]


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DOI: doi:10.1016/j.dnarep.2008.03.008

Abstract

Failure to maintain the integrity of DNA/chromatin can result in genome instability and an increased risk of cancer. The description of a number of human genetic disorders characterised not only by cancer predisposition but by a broader phenotype including neurodegeneration suggests that maintaining genome stability is also important for preserving post-mitotic neurons. The identification of genes associated with other neurodegenerative disorders provides further evidence for the importance of DNA damage response and DNA repair genes in protecting against neurodegeneration. This theme is further developed in this review.

Item Details

Item Type:Substantial Review
Keywords:spinocerebellar ataxia, DNA damage response, DNA repair, neurodegeneration, genome instability
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurology and Neuromuscular Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Gueven, N (Dr Nuri Guven)
ID Code:79291
Year Published:2008
Web of Science® Times Cited:13
Deposited By:Pharmacy
Deposited On:2012-08-29
Last Modified:2014-10-29
Downloads:0

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