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The orally active melanocortin-4 receptor antagonist BL-6020/979: a promising candidate for the treatment of cancer cachexia

Citation

Dallmann, R and Weyermann, P and Anklin, C and Boroff, M and Bray-French, K and Cardel, B and Courdier-Fruh, I and Deppe, H and Dubach-Powell, J and Erb, M and Haefeli, RH and Hennebohle, M and Herzner, H and Hufschmid, M and Marks, DL and Nordhoff, S and Papp, M and Rummey, C and Santos, G and Scharer, F and Siendt, H and Soeberdt, M and Sumanovski, LT and Terinek, M and Mondadori, C and Guven, N and Feurer, A, The orally active melanocortin-4 receptor antagonist BL-6020/979: a promising candidate for the treatment of cancer cachexia, Journal of Cachexia, Sarcopenia and Muscle, 2, (3) pp. 163-174. ISSN 2190-5991 (2011) [Refereed Article]


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Official URL: http://link.springer.com/

DOI: doi:10.1007/s13539-011-0039-1

Abstract

Background Under physiological conditions, the melanocortin system is a crucial part of the complex network regulating food intake and energy expenditure. In pathological states, like cachexia, these two parameters are deregulated, i.e., food intake is decreased and energy expenditure is increased—a vicious combination leading to catabolism. Agouti-related protein (AgRP), the endogenous antagonist at the melanocortin-4 receptor (MC-4R), was found to increase food intake and to reduce energy expenditure. This qualifies MC-4R blockade as an attractive mode of action for the treatment of cachexia. Based on this rationale, a novel series of small-molecule MC-4R antagonists was designed, from which the orally active compound BL-6020/979 (formerly known as SNT207979) emerged as the first promising development candidate showing encouraging pre-clinical efficacy and safety properties which are presented here. Methods and results BL-6020/979 is an orally available, selective and potent MC-4R antagonist with a drug-like profile. It increased food intake and decreased energy expenditure in healthy wild-type but not in MC-4R deficient mice. More importantly, it ameliorated cachexialike symptoms in the murine C26 adenocarcinoma model; with an effect on body mass and body composition and on the expression of catabolic genes. Moreover, BL-6020/979 showed antidepressant-like properties in the chronic mild stress model in rats and exhibits a favorable safety profile. Conclusion The properties of BL-6020/979 demonstrated in animal models and presented here make it a promising candidate suitable for further development towards a firstin- class treatment option for cachexia that potentially opens up the opportunity to treat two hallmarks of the disease, i.e., decreased food intake and increased energy expenditure, with one drug.

Item Details

Item Type:Refereed Article
Keywords:drug development
Research Division:Medical and Health Sciences
Research Group:Medical Biochemistry and Metabolomics
Research Field:Metabolic Medicine
Objective Division:Health
Objective Group:Other Health
Objective Field:Health not elsewhere classified
Author:Guven, N (Dr Nuri Guven)
ID Code:79266
Year Published:2011
Web of Science® Times Cited:22
Deposited By:Pharmacy
Deposited On:2012-08-29
Last Modified:2017-11-02
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