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Dysregulation of Ca2+ homeostasis in Alzheimer's disease: role in acetylcholinesterase production and AMPA receptor internalization

Citation

Small, DH, Dysregulation of Ca2+ homeostasis in Alzheimer's disease: role in acetylcholinesterase production and AMPA receptor internalization, Neurodegenerative Diseases, 10, (1-4) pp. 76-79. ISSN 1660-2854 (2012) [Refereed Article]


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Copyright Statement

Copyright 2012 Karger AG, Basel

DOI: doi:10.1159/000333126

Abstract

Amyloid-β (Aβ)-induced Ca2+ influx into neurons has been well described since it was first reported almost 20 years ago. Ca2+ influx can disrupt mechanisms of long-term potentiation and long-term depression and increase neuronal susceptibility to excitotoxicity. Our studies show that Aβ also causes an increase in acetylcholinesterase (AChE) levels and induces AMPA receptor internalization through Ca2+-dependent mechanisms. As Aβ-induced Ca2+ entry may increase neuronal excitability, the increase in AChE and the downregulation of cell surface AMPA receptors may be part of a homeostatic mechanism which maintains normal levels of cholinergic and glutamatergic signaling.

Item Details

Item Type:Refereed Article
Keywords:calcium, amyloid, acetylcholinesterase, AMPA receptor, synaptic scaling
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurosciences not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Neurodegenerative Disorders Related to Ageing
Author:Small, DH (Professor David Small)
ID Code:79251
Year Published:2012
Web of Science® Times Cited:6
Deposited By:Menzies Institute for Medical Research
Deposited On:2012-08-29
Last Modified:2017-11-06
Downloads:1 View Download Statistics

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