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Dysregulation of Ca2+ homeostasis in Alzheimer's disease: role in acetylcholinesterase production and AMPA receptor internalization
Citation
Small, DH, Dysregulation of Ca2+ homeostasis in Alzheimer's disease: role in acetylcholinesterase production and AMPA receptor internalization, Neurodegenerative Diseases, 10, (1-4) pp. 76-79. ISSN 1660-2854 (2012) [Refereed Article]
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Copyright Statement
Copyright 2012 Karger AG, Basel
Abstract
Amyloid-β (Aβ)-induced Ca2+ influx into neurons has been well described since it was first reported almost 20 years ago. Ca2+ influx can disrupt mechanisms of long-term potentiation and long-term depression and increase neuronal susceptibility to excitotoxicity. Our studies show that Aβ also causes an increase in acetylcholinesterase (AChE) levels and induces AMPA receptor internalization through Ca2+-dependent mechanisms. As Aβ-induced Ca2+ entry may increase neuronal excitability, the increase in AChE and the downregulation of cell surface AMPA receptors may be part of a homeostatic mechanism which maintains normal levels of cholinergic and glutamatergic signaling.
Item Details
Item Type: | Refereed Article |
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Keywords: | calcium, amyloid, acetylcholinesterase, AMPA receptor, synaptic scaling |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Neurosciences |
Research Field: | Neurosciences not elsewhere classified |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Small, DH (Professor David Small) |
ID Code: | 79251 |
Year Published: | 2012 |
Web of Science® Times Cited: | 6 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2012-08-29 |
Last Modified: | 2017-11-06 |
Downloads: | 1 View Download Statistics |
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