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Dysregulation of Ca2+ homeostasis in Alzheimer's disease: role in acetylcholinesterase production and AMPA receptor internalization
Citation
Small, DH, Dysregulation of Ca2+ homeostasis in Alzheimer's disease: role in acetylcholinesterase production and AMPA receptor internalization, Neurodegenerative Diseases, 10, (1-4) pp. 76-79. ISSN 1660-2854 (2012) [Refereed Article]
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Copyright Statement
Copyright 2012 Karger AG, Basel
Abstract
Amyloid-β (Aβ)-induced Ca2+ influx into neurons has been well described since it was first reported almost 20 years ago. Ca2+ influx can disrupt mechanisms of long-term potentiation and long-term depression and increase neuronal susceptibility to excitotoxicity. Our studies show that Aβ also causes an increase in acetylcholinesterase (AChE) levels and induces AMPA receptor internalization through Ca2+-dependent mechanisms. As Aβ-induced Ca2+ entry may increase neuronal excitability, the increase in AChE and the downregulation of cell surface AMPA receptors may be part of a homeostatic mechanism which maintains normal levels of cholinergic and glutamatergic signaling.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | calcium, amyloid, acetylcholinesterase, AMPA receptor, synaptic scaling |
| Research Division: | Medical and Health Sciences |
| Research Group: | Neurosciences |
| Research Field: | Neurosciences not elsewhere classified |
| Objective Division: | Health |
| Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
| Objective Field: | Neurodegenerative Disorders Related to Ageing |
| Author: | Small, DH (Professor David Small) |
| ID Code: | 79251 |
| Year Published: | 2012 |
| Web of Science® Times Cited: | 6 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2012-08-29 |
| Last Modified: | 2017-11-06 |
| Downloads: | 1 View Download Statistics |
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