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A ketogenic diet favorably affects serum biomarkers for cardiovascular disease in normal-weight men

Citation

Sharman, MJ and Kraemer, WJ and Love, DM and Avery, NG and Gomez, AL and Scheett, TP and Volek, JS, A ketogenic diet favorably affects serum biomarkers for cardiovascular disease in normal-weight men, Journal of Nutrition, 2002 Jul, (132(7)) pp. 1879-85. ISSN 0022-3166 (2002) [Refereed Article]


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Copyright Statement

Copyright 2002 American Society for Nutritional Science

Official URL: http://jn.nutrition.org/

Abstract

Very low-carbohydrate (ketogenic) diets are popular yet little is known regarding the effects on serum biomarkers for cardiovascular disease (CVD). This study examined the effects of a 6-wk ketogenic diet on fasting and postprandial serum biomarkers in 20 normal-weight, normolipidemic men. Twelve men switched from their habitual diet (17% protein, 47% carbohydrate and 32% fat) to a ketogenic diet (30% protein, 8% carbohydrate and 61% fat) and eight control subjects consumed their habitual diet for 6 wk. Fasting blood lipids, insulin, LDL particle size, oxidized LDL and postprandial triacylglycerol (TAG) and insulin responses to a fat-rich meal were determined before and after treatment. There were significant decreases in fasting serum TAG (-33%), postprandial lipemia after a fat-rich meal (-29%), and fasting serum insulin concentrations (-34%) after men consumed the ketogenic diet. Fasting serum total and LDL cholesterol and oxidized LDL were unaffected and HDL cholesterol tended to increase with the ketogenic diet (+11.5%; P = 0.066). In subjects with a predominance of small LDL particles pattern B, there were significant increases in mean and peak LDL particle diameter and the percentage of LDL-1 after the ketogenic diet. There were no significant changes in blood lipids in the control group. To our knowledge this is the first study to document the effects of a ketogenic diet on fasting and postprandial CVD biomarkers independent of weight loss. The results suggest that a short-term ketogenic diet does not have a deleterious effect on CVD risk profile and may improve the lipid disorders characteristic of atherogenic dyslipidemia.

Item Details

Item Type:Refereed Article
Keywords:triglycerides, postprandial lipemia, lipoprotein subclasses
Research Division:Medical and Health Sciences
Research Group:Nutrition and Dietetics
Research Field:Nutrition and Dietetics not elsewhere classified
Objective Division:Health
Objective Group:Public Health (excl. Specific Population Health)
Objective Field:Nutrition
Author:Sharman, MJ (Dr Matt Sharman)
ID Code:79124
Year Published:2002
Deposited By:Health Sciences A
Deposited On:2012-08-17
Last Modified:2013-03-01
Downloads:0

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