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Weight loss leads to reductions in inflammatory biomarkers after a very-low-carbohydrate diet and a low-fat diet in overweight men
Citation
Sharman, MJ and Volek, JS, Weight loss leads to reductions in inflammatory biomarkers after a very-low-carbohydrate diet and a low-fat diet in overweight men, Clinical Science, 107 pp. 365-369. ISSN 0143-5221 (2004) [Refereed Article]
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Copyright Statement
Copyright 2004 The Biochemical Society
Abstract
In recent years, it has become apparent that low-grade vascular inflammation plays a key role in all stages of the pathogenesis of atherosclerosis. Weight loss has been shown to improve blood inflammatory markers; however, it is unknown if weight-loss diets varying in macronutrient composition differentially affect inflammatory responses. The primary purpose of the present study was to compare a very-low-carbohydrate diet and a low-fat weight-loss diet on inflammatory biomarkers in overweight men. In a randomized cross-over design, 15 overweight men (body fat, >25%; body mass index, 34 kg/m2) consumed two experimental weight-loss diets for two consecutive 6-week periods: a very-low-carbohydrate diet (<10% energy via carbohydrate) and a low-fat diet (<30% energy via fat). Both the low-fat and the very-low-carbohydrate diets resulted in significant decreases in absolute concentrations of hsTNF-alpha (high-sensitivity tumour necrosis factor-alpha), hsIL-6 (high-sensitivity interleukin-6), hsCRP (high-sensitivity C-reactive protein) and sICAM-1 (soluble intercellular cell-adhesion molecule-1). There was no significant change in absolute sP-selectin (soluble P-selectin) concentrations after either diet. Normalized inflammatory values represented as the delta change per 1 kg reduction in body mass showed a significant difference between the two diets only for sP-selectin (P<0.05). In summary, energy-restricted low-fat and very-low-carbohydrate diets both significantly decreased several biomarkers of inflammation. These data suggest that, in the short-term, weight loss is primarily the driving force underlying the reductions in most of the inflammatory biomarkers.
Item Details
Item Type: | Refereed Article |
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Research Division: | Health Sciences |
Research Group: | Sports science and exercise |
Research Field: | Exercise physiology |
Objective Division: | Health |
Objective Group: | Evaluation of health and support services |
Objective Field: | Evaluation of health and support services not elsewhere classified |
UTAS Author: | Sharman, MJ (Dr Matt Sharman) |
ID Code: | 78982 |
Year Published: | 2004 |
Web of Science® Times Cited: | 84 |
Deposited By: | Health Sciences A |
Deposited On: | 2012-08-10 |
Last Modified: | 2012-09-14 |
Downloads: | 2 View Download Statistics |
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