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Cortitrol supplementation reduces serum cortisol responses to physical stress


Kraemer, WJ and French, DN and Spiering, BA and Volek, JS and Sharman, MJ and Ratamess, NA and Judelson, DA and Silvestre, R and Watson, G and Gomez, AL and Maresh, CM, Cortitrol supplementation reduces serum cortisol responses to physical stress, Metabolism: Clinical and Experimental, 2005 May, (54(5)) pp. 657-68. ISSN 0026-0495 (2005) [Refereed Article]

DOI: doi:10.1016/j.metabol.2004.12.010


The supplement Cortitrol was formulated to mitigate the cortisol response to physiological and psychological stress. Therefore, the purpose of this study was to examine the effects of Cortitrol on serum cortisol concentrations before, during, and after a high-intensity resistance exercise protocol (EX) and a resting control day (REST). We used a matched, balanced, randomized, double-blind, placebo-controlled, cross-over design. Blood samples were obtained at matching time points during EX and REST. Cortitrol significantly ( P < .05) reduced cortisol area under the curve concentrations during REST. During EX, Cortitrol reduced cortisol concentrations at 20, 10, and 0 minutes pre-exercise, at mid-exercise, immediately post-exercise, and at 5 minutes post-exercise. In addition, serum cortisol and plasma adrenocorticotropin hormone area under the curve concentrations during EX were significantly lower after Cortitrol than placebo. Furthermore, Cortitrol significantly reduced free radical production. This was indicated by significantly lower plasma malondialdehyde concentrations at the 65-minute post-exercise time point during REST, and at pre-exercise, immediate post-exercise, and 65 minutes post-exercise during EX. Serum total testosterone, free testosterone, dehydroepiandrosterone, and growth hormone showed exercise-induced increases but no treatment effects. These data demonstrate that Cortitrol was effective in modulating the physiological stress responses of exercise from the anticipatory rises before physical stress and into early recovery by reducing cortisol and associated free radical production.

Item Details

Item Type:Refereed Article
Research Division:Health Sciences
Research Group:Sports science and exercise
Research Field:Exercise physiology
Objective Division:Health
Objective Group:Evaluation of health and support services
Objective Field:Evaluation of health and support services not elsewhere classified
UTAS Author:Sharman, MJ (Dr Matt Sharman)
UTAS Author:Watson, G (Dr Greig Watson)
ID Code:78953
Year Published:2005
Web of Science® Times Cited:20
Deposited By:Health Sciences A
Deposited On:2012-08-08
Last Modified:2012-08-08

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