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Effect of biologic therapy on radiological progression in rheumatoid arthritis: what does it add to methotrexate?

Citation

Jones, G and Darian-Smith, E and Kwok, M and Winzenberg, T, Effect of biologic therapy on radiological progression in rheumatoid arthritis: what does it add to methotrexate?, Biologics, 6 pp. 155-161. ISSN 1177-5491 (2012) [Refereed Article]


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Copyright Statement

Copyright 2012 Dove Medical Press

DOI: doi:10.2147/BTT.S20659

Abstract

There have been substantial advances in the treatment of rheumatoid arthritis in recent years. Traditional disease-modifying antirheumatic drugs (DMARDs) have been shown to have small effects on the progression of radiographic damage. This quantitative overview summarizes the evidence for biologic DMARDS and radiographic damage either alone or in combination with methotrexate. Two outcomes were used (standardized mean difference and odds of progression). A total of 21 trials were identified of which 18 had useable data. For biologic monotherapy, tocilizumab, adalimumab, and etanercept were significantly better than methotrexate, with tocilizumab ranking first in both outcomes while golimumab was ineffective in both outcomes. For a biologic in combination with methotrexate compared with methotrexate alone, most therapies studied (etanercept, adalimumab, infliximab, certolizumab, tocilizumab, and rituximab) were effective at slowing X-ray progression using either outcome, with infliximab ranking first in both outcomes. The exceptions to this were golimumab (no effect on standardized mean difference) and abatacept (no effect on odds of progression). This effect was additional to methotrexate; thus, the overall benefit is moderate to large in magnitude, which is clearly of major clinical significance for sufferers of rheumatoid arthritis and supports the use of biologic DMARDs in those with a poor disease prognosis.

Item Details

Item Type:Refereed Article
Keywords:rheumatoid, trials, meta-analysis, radiographs, biologic, disease-modifying antirheumatic drugs, DMARDs
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Jones, G (Professor Graeme Jones)
Author:Darian-Smith, E (Dr Erica Darian-Smith)
Author:Kwok, M (Mr Michael Kwok)
Author:Winzenberg, T (Professor Tania Winzenberg)
ID Code:78517
Year Published:2012
Deposited By:Menzies Institute for Medical Research
Deposited On:2012-07-04
Last Modified:2013-11-18
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