Khalafallah, AA and Morse, M and Al-Barzan, AM and Adams, M and Dennis, A and Bates, G and Robertson, I and Seaton, D and Brain, T, D-Dimer levels at different stages of pregnancy in Australian women: A single centre study using two different immunoturbidimetric assays, Thrombosis Research, 130, (3) pp. e171-e177. ISSN 0049-3848 (2012) [Refereed Article]
Copyright 2012 Elsevier Ltd.
Background: To date there is minimal data available on D-Dimer levels at different stages of pregnancy.
Patients and methods: We prospectively measured D-Dimer levels in 632 consecutive pregnant women from March 2007 to January 2009. The median age of the participants was 31years (range; 18-42) with a median weight of 78 kilograms (range; 46-137). All subjects were investigated during each trimester with two different immunoturbidimetric assays; D-Dimer PLUS and INNOVANCE D-Dimer. D-Dimer levels were determined using a Sysmex® CA 1500 analyser.
Results: Our data demonstrate that D-Dimer levels in pregnancy show different patterns of rise within the first trimester, depending on the assay used; D-Dimer PLUS = 0.88 (SD: mean ratio), INNOVANCE D-Dimer = 0.72 (SD: mean ratio). Furthermore, the rise in mean results was greater for the INNOVANCE D-Dimer assay compared to the D-Dimer PLUS assay as shown by the ratio of third to first trimester results of 3.68 and 1.96 respectively. Both D-Dimer assays demonstrated moderate levels of intra-subject variability, with overall mean CVs of 16.5% (D-Dimer PLUS) and 16.9% (INNOVANCE D-Dimer). Furthermore, we studied the association between D-Dimer levels and occurrence of diseases of pregnancy. For both assays, there was no consistently interpretable evidence of an association between raised mean D-Dimer levels or rising D-Dimer levels and any of the diseases or conditions associated with pregnancy.
Conclusion: Our data suggest that the INNOVANCE D-Dimer assay increases significantly with the advancement of pregnancy, and is more sensitive than D-Dimer PLUS assay in the pregnant population.
|Item Type:||Refereed Article|
|Keywords:||pregnancy, INNOVANCE D-Dimer, D-Dimer PLUS, outcome|
|Research Division:||Medical and Health Sciences|
|Research Group:||Cardiorespiratory Medicine and Haematology|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Blood Disorders|
|Author:||Khalafallah, AA (Professor Alhossain Khalafallah)|
|Author:||Morse, M (Mr Michael Morse)|
|Author:||Al-Barzan, AM (Dr Abdul Majeed)|
|Author:||Adams, M (Dr Murray Adams)|
|Author:||Dennis, A (Associate Professor Amanda Dennis)|
|Author:||Robertson, I (Dr Iain Robertson)|
|Web of Science® Times Cited:||11|
|Deposited By:||Health Sciences A|
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