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Changes in cystic fibrosis mortality in Australia, 1979-2005

Citation

Reid, DW and Blizzard, CL and Shugg, DM and Flowers, C and Cash, CE and Greville, HM, Changes in cystic fibrosis mortality in Australia, 1979-2005, Medical Journal of Australia, 195, (7) pp. 392-395. ISSN 0025-729X (2011) [Refereed Article]


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Copyright Statement

Copyright 2011 Australasian Medical Publishing Company

DOI: doi:10.5694/mja10.11229

Abstract

Objective: To assess mortality trends among people with cystic fibrosis (CF) in Australia. Design and setting: We augmented Australian summary data for deaths from CF registered during 1979-2005 with information from Australian transplant centres on lung transplantation among CF patients for 1989-2005 to allow us to follow trends in all "mortality events" (death or lung transplantation). Main outcome measure: Age at death or lung transplantation. Results: Between 1979 and 2005, the mean age at death increased from 12.2 years to 27.9 years for males and from 14.8 years to 25.3 years for females. Overall, female deaths in childhood (0-14 years) occurred at an age-standardised rate of 0.40 per 100 000 (95% Cl, 0.34-0.45) during 1979-2005, which exceeded the corresponding rate for males of 0.24 (95% CI, 0.20-0.28) per 100 000. Among 0-14-year-old boys, event rates declined markedly after 1989, but they declined later and more gradually for girls, with the result that the age-standardised rate for girls was 2.38 times that of boys during 1989-2005 (95% CI, 1.69-3.36). Conclusions: The pattern of CF mortality in Australia has changed substantially. Mortality rates continue to be higher for girls than for boys, but death in childhood has become uncommon. Survival has increased since 1979, but females continue to have reduced length of life.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Respiratory Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Respiratory System and Diseases (incl. Asthma)
Author:Blizzard, CL (Associate Professor Leigh Blizzard)
Author:Shugg, DM (Mrs Dace Shugg)
Author:Flowers, C (Mrs Ceri Flowers)
Author:Cash, CE (Ms Catherine Cash)
ID Code:78129
Year Published:2011
Web of Science® Times Cited:17
Deposited By:Menzies Institute for Medical Research
Deposited On:2012-06-15
Last Modified:2012-08-30
Downloads:0

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