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Infant anthropometry, early life infection, and subsequent risk of type 1 diabetes mellitus: a prospective birth cohort study


Ponsonby, AL and Pezic, A and Cochrane, J and Cameron, FJ and Pascoe, M and Kemp, A and Dwyer, T, Infant anthropometry, early life infection, and subsequent risk of type 1 diabetes mellitus: a prospective birth cohort study, Pediatric Diabetes, 12, (4) pp. 313-321. ISSN 1399-543X (2011) [Refereed Article]

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Copyright Statement

Copyright 2011 John Wiley & Sons A/S

DOI: doi:10.1111/j.1399-5448.2010.00693.x


Background: Higher birthweight is associated with increased type 1 diabetes mellitus (T1DM) risk, but the contribution of higher adiposity or lean mass is unclear. In this Tasmanian infant cohort, early upper respiratory infection has been associated with higher asthma risk. Patients and methods: Eligible infants represented one-fifth of live births in Tasmania, 1988–1995. Hospital interview data (day 6) were obtained on 96.3% (10 628/11 040), home (5 wk) visit data (38 d) on 92.9% (9876/10 628) of those, then a phone (12 wk) interview (87 d). Tricep and subscapular skinfold measures and upper arm circumference were recorded at the first two interviews. T1DM cases (n = 26) arising from the age of 16 or under in Tasmania from 1988 to 2006 were ascertained. Results: Higher birthweight [adjusted odds ratio (AOR) 2.82 (95% CI 1.31–6.09)], lean mid-upper arm circumference [AOR 1.76 (95% CI 1.16–2.66)], not skinfold measures, were associated with T1DM risk. Children with an early upper respiratory tract infection by 5-wk visit [AOR 2.74 (95% CI 1.19–6.32)] or ear infection by 12-wk interview [AOR 3.44 (95% CI 1.00–11.79)] were also at higher risk. Putative markers of altered microbial exposure such as resident density were not associated with T1DM risk but the effect of increasing birth order on T1DM risk differed for older (AOR 0.41, p = 0.02) than young mother (AOR 2.45, p = 0.01); difference in effect, p = 0.001. Conclusion: In this cohort, early upper respiratory tract infection was associated with T1DM risk, as had been previously found for asthma, consistent with immunoinflammatory upregulation. Using the detailed anthropometric measures available, the link between higher birthweight and T1DM did not appear to reflect increased adiposity.

Item Details

Item Type:Refereed Article
Keywords:anthropometry; birth order; infection; prospective cohort; T1D
Research Division:Biomedical and Clinical Sciences
Research Group:Medical biochemistry and metabolomics
Research Field:Medical biochemistry - carbohydrates
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Ponsonby, AL (Professor Anne Ponsonby)
UTAS Author:Cochrane, J (Mrs Jennifer Cochrane)
UTAS Author:Dwyer, T (Professor Terry Dwyer)
ID Code:78052
Year Published:2011
Web of Science® Times Cited:9
Deposited By:Menzies Institute for Medical Research
Deposited On:2012-06-13
Last Modified:2017-11-06

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