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Associations between serum levels of inflammatory markers and change in knee pain over 5 years in older adults: a prospective cohort study
Citation
Stannus, OP and Jones, G and Blizzard, L and Cicuttini, FM and Ding, C, Associations between serum levels of inflammatory markers and change in knee pain over 5 years in older adults: a prospective cohort study, Annals of The Rheumatic Diseases, 72, (4) pp. 535-540. ISSN 1468-2060 (2012) [Refereed Article]
Copyright Statement
Copyright 2012 BMJ Publishing Group
DOI: doi:10.1136/annrheumdis-2011-201047
Abstract
Objective: To determine the association between inflammatory markers and change in knee pain over 5 years.
Methods: A total of 149 randomly selected subjects (mean 63 years, range 52-78; 46% female) was studied. Serum levels of high sensitivity C-reactive protein (hs-CRP), tumour necrosis factor alpha (TNF-α) and interleukin (IL)-6 were measured at baseline and 2.7 years later. Knee pain was recorded using the Western Ontario and McMasters osteoarthritis index questionnaire at baseline and 5 years later. Knee radiographic osteoarthritis of both knees was assessed at baseline, and knee bone marrow lesions, joint effusion and cartilage defects were determined using T1 or T2-weighted fat saturated MRI.
Results: After adjustment for confounding variables, baseline hs-CRP was positively associated with change in total knee pain (β=0.33 per mg/l, p=0.032), as well as change in the pain at night in bed (β=0.12 per ml/pg, p=0.010) and while sitting/lying (β=0.12 per ml/pg, p=0.002). Change in hs-CRP was also associated with change in knee pain at night and when sitting/lying (both p<0.05). Baseline TNFα and IL-6 were associated with change in pain while standing (β=0.06 per ml/pg, p=0.033; β=0.16 per ml/pg, p=0.035, respectively), and change in TNFα was positively associated with change in total knee pain (β=0.66 ml/pg, p=0.020) and change in pain while standing (β=0.26 ml/pg, p=0.002). Adjustment for radiographic osteoarthritis or MRI-detected structural abnormalities led to no or minor attenuation of these associations.
Conclusion: Systemic inflammation is an independent predictor of worsening knee pain over 5 years.
Item Details
Item Type: | Refereed Article |
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Keywords: | inflammatory markers, knee pain, osteoarthritis, joint effusion, cartilage defects, C-reactive protein, CRP, tumour necrosis factor alpha, TNF, interleukin-6, IL6 |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Clinical sciences |
Research Field: | Rheumatology and arthritis |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Stannus, OP (Mr Oliver Stannus) |
UTAS Author: | Jones, G (Professor Graeme Jones) |
UTAS Author: | Blizzard, L (Professor Leigh Blizzard) |
UTAS Author: | Ding, C (Professor Chang-Hai Ding) |
ID Code: | 78037 |
Year Published: | 2012 |
Web of Science® Times Cited: | 145 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2012-06-13 |
Last Modified: | 2017-11-02 |
Downloads: | 0 |
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