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Haemophilus haemolyticus as a potential reservoir for ftsI gene mutations and altered penicillin-binding protein 3 mediated resistance in Haemophilus influenzae

Citation

Tristram, SG and Witherden, E, Haemophilus haemolyticus as a potential reservoir for ftsI gene mutations and altered penicillin-binding protein 3 mediated resistance in Haemophilus influenzae, Proceedings of European Congress on Clinical Microbiology and Infectious Diseases, March-April 2012, London, pp. 1-2. (2012) [Conference Extract]


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Abstract

B-lactamase-negative ampicillin-resistant (BLNAR) strains of H. influenzae are being increasingly recognised. BLNAR strains are characterized by specific ftsI gene mutations and associated amino acid substitutions in the encoded penicillin binding protein 3 (PBP3). The N526K (BLNAR defining) PBP3 substitution occurs in almost all BLNAR strains and resistance is enhanced by further substitutions (BLNAR associated) at other sites. It is generally accepted that most BLNAR strains emerge from de novo ftsI mutations in previously susceptible strains although there is some evidence of inter-strain horizontal transfer of mutated ftsI genes. Significantly, there has been one report of horizontal transfer of the ftsI gene from the respiratory commensal H. haemolyticus to H. influenzae. A role was proposed for H. haemolyticus as a reservoir of ftsI genes to mediate BLNAR type resistance in H. influenzae through recombination and formation of mosaic ftsI genes. Little is known about the frequency, nature or effect on susceptibility of ftsI mutations in H. haemolyticus and the aims of this study are to investigate this.

Item Details

Item Type:Conference Extract
Keywords:haemophilus, antibiotic resistance
Research Division:Medical and Health Sciences
Research Group:Medical Microbiology
Research Field:Medical Bacteriology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Infectious Diseases
Author:Tristram, SG (Dr Stephen Tristram)
Author:Witherden, E (Ms Elizabeth Witherden)
ID Code:77825
Year Published:2012
Deposited By:Health Sciences A
Deposited On:2012-05-30
Last Modified:2013-09-03
Downloads:1 View Download Statistics

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