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In vitro and in vivo efficacy of anthelmintic compounds against blood fluke (Cardicola forsteri)
Citation
Hardy-Smith, P and Ellis, D and Humphrey, J and Evans, Matthew and Evans, E and Rough, K and Valdenegro, V and Nowak, B, In vitro and in vivo efficacy of anthelmintic compounds against blood fluke (Cardicola forsteri), Aquaculture, 334-337 pp. 39-44. ISSN 0044-8486 (2012) [Refereed Article]
Copyright Statement
Copyright 2012 Elsevier B.V.
DOI: doi:10.1016/j.aquaculture.2011.12.037
Abstract
Blood fluke, Cardicola forsteri, infects Southern Bluefin Tuna, particularly during ranching. Efficacy of four anthelmintics
was tested against this parasite. There was an agreement between in vitro and in vivo results. Praziquantel
was the only effective anthelmintic. It was the most potent anthelmintic in decreasing fluke
responsiveness in vitro, with concentrations ranging between 1.5 μg/mL and 200 μg/mL stopping adult
fluke response within less than 5 min. In vivo, both the higher (150 mg/kg) and the lower (75 mg/kg) dose
praziquantel treatment resulted in a significant reduction of the number of flukes present in the hearts. A significant
effect of treatment on the mean number of blood fluke eggs per cm2 of tuna myocardium was observed,
with fish treated with either of the two doses of praziquantel having at least 6 times lower
numbers of eggs in their hearts. Control fish and fish treated with praziquantel (both doses) and lower
dose Closal had very low average number of eggs per cm2 of gill and were significantly lower than in fish treated
with fenbendazole. While this research shows that praziquantel is the treatment of choice against blood
fluke, C. forsteri, further research is needed to determine optimum dose, best treatment application method,
palatability and any potential side effects.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | southern bluefin tuna, ranching, fish parasite, treatment, blood fluke, Cardicola forsteri, anthelmintics |
| Research Division: | Agricultural, Veterinary and Food Sciences |
| Research Group: | Fisheries sciences |
| Research Field: | Fish pests and diseases |
| Objective Division: | Animal Production and Animal Primary Products |
| Objective Group: | Fisheries - aquaculture |
| Objective Field: | Aquaculture tuna |
| UTAS Author: | Ellis, D (Mr David Ellis) |
| UTAS Author: | Evans, Matthew (Mr Matthew Evans) |
| UTAS Author: | Evans, E (Dr Evan Evans) |
| UTAS Author: | Valdenegro, V (Miss Victoria Valdenegro) |
| UTAS Author: | Nowak, B (Professor Barbara Nowak) |
| ID Code: | 77805 |
| Year Published: | 2012 |
| Web of Science® Times Cited: | 32 |
| Deposited By: | NC Marine Conservation and Resource Sustainability |
| Deposited On: | 2012-05-30 |
| Last Modified: | 2017-11-03 |
| Downloads: | 0 |
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