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Neuroprotection and regeneration by extracellular metallothionein via lipoprotein-receptor-related proteins


West, AK and Leung, JYK and Chung, RS, Neuroprotection and regeneration by extracellular metallothionein via lipoprotein-receptor-related proteins, Journal of Biological Inorganic Chemistry, 16, (7) pp. 1115-1122. ISSN 0949-8257 (2011) [Refereed Article]

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Copyright 2011 SBIC

DOI: doi:10.1007/s00775-011-0817-4


Metallothionein has a well-documented pro- tective and proregenerative effect in the mammalian brain, particularly following physical trauma and ischemia or during the onset of neurodegenerative disease. A range of mechanisms have been established for this, including metallothionein�s metal binding properties and its ability to scavenge free radicals. In recent years it has become apparent that metallothionein is present in the extracellular compartment of the central nervous system and that it can interact with cell surface receptors of the lipoprotein- receptor-related protein family, including lipoprotein- receptor-related protein 1 (LRP1) and megalin. These interactions activate intracellular pathways which are consistent with many of the observed effects of metallo- thionein in the central nervous system, including its effects on neurons, glial cells, and cells of the immune system. The evidence describing the release, receptor interactions, and subsequent physiological consequences of metallothi- onein is discussed in this review.

Item Details

Item Type:Refereed Article
Keywords:Metallothionein; Neuron; Astrocyte; Lipoprotein-receptor-related protein; Megalin
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Central nervous system
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:West, AK (Professor Adrian West)
UTAS Author:Leung, JYK (Dr Jacqueline Leung)
UTAS Author:Chung, RS (Associate Professor Roger Chung)
ID Code:77618
Year Published:2011
Web of Science® Times Cited:20
Deposited By:Menzies Institute for Medical Research
Deposited On:2012-05-12
Last Modified:2017-11-06

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