Scott, DS and Blizzard, L and Fell, J and Jones, G, Prospective study of self-reported pain, radiographic osteoarthritis, sarcopenia progression, and falls risk in community-dwelling older adults, Arthritis Care & Research, 64, (1) pp. 30-37. ISSN 2151-464X (2012) [Refereed Article]
Copyright 2012 American College of Rheumatology
Official URL: http://dx.doi.org/10.1002/14651858.CD009691
OBJECTIVE: To examine the potential role of self-reported joint pain, stiffness, and dysfunction, and radiographic osteoarthritis (ROA), in sarcopenia progression and falls risk in older adults.
METHODS: Seven hundred nine older adults (50% women, mean ± SD age 62 ± 7 years) were examined at baseline and followup (mean ± SD 2.6 ± 0.4 years). ROA was assessed using the Altman atlas, and pain at 7 anatomic sites was self-reported. Dual x-ray absorptiometry assessed leg lean mass, dynamometry assessed knee extension and whole leg strength, leg muscle quality (LMQ) was calculated as whole leg strength relative to leg lean mass, and the Physiological Profile Assessment assessed falls risk.
RESULTS: In women only, baseline knee pain predicted a greater decline in knee extension strength, whole leg strength, and LMQ, and a greater increase in falls risk. Severe knee pain, stiffness, and dysfunction predicted greater declines in knee extension strength and increases in falls risk (all P < 0.05). Hip pain also predicted a greater decline in knee extension strength (-1.53 kg; 95% confidence interval [95% CI] -2.95, -0.11). No associations were observed between pain and sarcopenia indicators in men. Somewhat surprisingly, higher baseline total knee ROA score predicted a greater increase in mean leg lean mass (0.05 kg; 95% CI 0.02, 0.08) in both sexes. A path analysis demonstrated that knee ROA may contribute to declines in LMQ in women, through increases in pain, stiffness, and dysfunction.CONCLUSION: Knee and hip pain may directly contribute to the progression of sarcopenia and increased falls risk in older women.
|Item Type:||Refereed Article|
|Research Division:||Medical and Health Sciences|
|Research Group:||Clinical Sciences|
|Research Field:||Rheumatology and Arthritis|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Skeletal System and Disorders (incl. Arthritis)|
|Author:||Scott, DS (Mr David Scott)|
|Author:||Blizzard, L (Associate Professor Leigh Blizzard)|
|Author:||Fell, J (Associate Professor James Fell)|
|Author:||Jones, G (Professor Graeme Jones)|
|Web of Science® Times Cited:||33|
|Deposited By:||Menzies Institute for Medical Research|
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