eCite Digital Repository

Burn injury has a systemic effect on reinnervation of skin and restoration of nociceptive function


Morellini, NM and Fear, MW and Rea, S and West, AK and Wood, FM and Dunlop, SA, Burn injury has a systemic effect on reinnervation of skin and restoration of nociceptive function, Wound Repair and Regeneration, 20, (3) pp. 367-377. ISSN 1067-1927 (2012) [Refereed Article]

Restricted - Request a copy

Copyright Statement

Copyright 2012 Would Healing Society

DOI: doi:10.1111/j.1524-475X.2012.00787.x


Burn injury can lead to abnormal sensory function at both the injury and at distant uninjured sites. Here, we used a mouse model to investigate return of nociceptive function and reinnervation of the skin at the wound and uninjured distant sites following a 3% total burn surface area full-thickness burn injury. We have previously shown that topical application of zinc-metallothionein-IIA (Zn7-MT-IIA) accelerates healing following burn injury, and here, we investigated the potential of Zn7-MT-IIA to enhance reinnervation and sensory recovery. In all burn-injured animals, there was a significant reduction in nociceptive responses (Semmes-Weinstein filaments) at locations near and distant to the wound up to 8 weeks following injury. Cutaneous nerve reinnervation (assessed using protein gene product 9.5 immunohistochemistry) of the wound center was slow in the epidermis but rapid in the dermis. In the dermis, nerves subsequently degenerated both at the wound center and in distant uninjured areas. In contrast, epidermal nerve densities in the distant uninjured areas returned to normal, uninjured levels. Zn7-MT-IIA did not influence return of nociceptive function nor reinnervation. We conclude that burn injury compromises nociceptive function and nerve regeneration both at the injury site and systemically; thus, therapies in addition to Zn7-MT-IIA should be explored to return normal sensory function.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Peripheral nervous system
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:West, AK (Professor Adrian West)
ID Code:77578
Year Published:2012
Web of Science® Times Cited:12
Deposited By:Menzies Institute for Medical Research
Deposited On:2012-05-04
Last Modified:2013-04-16

Repository Staff Only: item control page