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Absence of a relationship between subjective memory complaint and objective memory impairment in mild cognitive impairment (MCI): is it time to abandon subjective memory complaint as an MCI diagnostic criterion?

Citation

Lenehan, ME and Klekociuk, SZ and Summers, MJ, Absence of a relationship between subjective memory complaint and objective memory impairment in mild cognitive impairment (MCI): is it time to abandon subjective memory complaint as an MCI diagnostic criterion?, International Psychogeriatrics, 24, (9) pp. 1505-1514. ISSN 1041-6102 (2012) [Refereed Article]


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Copyright Statement

Copyright 2012 International Psychogeriatric Association

DOI: doi:10.1017/S1041610212000695

Abstract

Background: Subjective memory complaints are a requirement in the diagnosis of mild cognitive impairment (MCI) as they are thought to indicate a decline in objective memory performance. However, recent research suggests that the relationship between subjective memory complaint and objective memory impairment is less clear. Thus, it is possible that many people without subjective memory complaints who develop Alzheimer’s disease are precluded from a diagnosis of MCI. Methods: The present study examined the relationship between subjective memory complaint assessed using theMultifactorial Memory Questionnaire (MMQ) and objective memory impairment assessed using standard neuropsychological measures in cases of amnestic MCI (n = 48), non-amnestic MCI (n = 27), and unimpaired healthy participants (n = 64). Results: Correlational and regression analyses indicated that subjective memory complaints displayed a poor relationship with objective memory performance. A subsequent discriminant function analysis indicated that subjective memory complaints failed to improve the diagnostic accuracy of MCI and resulted in increased rates of false negative and false positive diagnoses. Conclusion: The results of the present study suggest that a diagnostic criterion of subjective memory complaint reduces the accuracy of MCI diagnosis, resulting in an elevated rate of false positive and false negative diagnoses. The results of this study in conjunction with recent research indicate that a criterion of subjective memory complaint should be discarded from emerging diagnostic criteria for MCI.

Item Details

Item Type:Refereed Article
Keywords:subjective, objective, memory impairment, mild cognitive impairment, diagnosis
Research Division:Psychology and Cognitive Sciences
Research Group:Psychology
Research Field:Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Neurodegenerative Disorders Related to Ageing
Author:Lenehan, ME (Miss Megan Lenehan)
Author:Klekociuk, SZ (Dr Shannon Klekociuk)
Author:Summers, MJ (Dr Mathew Summers)
ID Code:77559
Year Published:2012
Web of Science® Times Cited:39
Deposited By:Psychology
Deposited On:2012-05-02
Last Modified:2017-11-06
Downloads:4 View Download Statistics

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