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Absence of a relationship between subjective memory complaint and objective memory impairment in mild cognitive impairment (MCI): is it time to abandon subjective memory complaint as an MCI diagnostic criterion?
Citation
Lenehan, ME and Klekociuk, SZ and Summers, MJ, Absence of a relationship between subjective memory complaint and objective memory impairment in mild cognitive impairment (MCI): is it time to abandon subjective memory complaint as an MCI diagnostic criterion?, International Psychogeriatrics, 24, (9) pp. 1505-1514. ISSN 1041-6102 (2012) [Refereed Article]
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Copyright Statement
Copyright 2012 International Psychogeriatric Association
DOI: doi:10.1017/S1041610212000695
Abstract
Background: Subjective memory complaints are a requirement in the diagnosis of mild cognitive impairment
(MCI) as they are thought to indicate a decline in objective memory performance. However, recent research
suggests that the relationship between subjective memory complaint and objective memory impairment is less
clear. Thus, it is possible that many people without subjective memory complaints who develop Alzheimer’s
disease are precluded from a diagnosis of MCI.
Methods: The present study examined the relationship between subjective memory complaint assessed using
theMultifactorial Memory Questionnaire (MMQ) and objective memory impairment assessed using standard
neuropsychological measures in cases of amnestic MCI (n = 48), non-amnestic MCI (n = 27), and unimpaired
healthy participants (n = 64).
Results: Correlational and regression analyses indicated that subjective memory complaints displayed a poor
relationship with objective memory performance. A subsequent discriminant function analysis indicated that
subjective memory complaints failed to improve the diagnostic accuracy of MCI and resulted in increased
rates of false negative and false positive diagnoses.
Conclusion: The results of the present study suggest that a diagnostic criterion of subjective memory complaint
reduces the accuracy of MCI diagnosis, resulting in an elevated rate of false positive and false negative
diagnoses. The results of this study in conjunction with recent research indicate that a criterion of subjective
memory complaint should be discarded from emerging diagnostic criteria for MCI.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | subjective, objective, memory impairment, mild cognitive impairment, diagnosis |
| Research Division: | Psychology and Cognitive Sciences |
| Research Group: | Psychology |
| Research Field: | Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology) |
| Objective Division: | Health |
| Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
| Objective Field: | Neurodegenerative Disorders Related to Ageing |
| Author: | Lenehan, ME (Miss Megan Lenehan) |
| Author: | Klekociuk, SZ (Dr Shannon Klekociuk) |
| Author: | Summers, MJ (Dr Mathew Summers) |
| ID Code: | 77559 |
| Year Published: | 2012 |
| Web of Science® Times Cited: | 35 |
| Deposited By: | Psychology |
| Deposited On: | 2012-05-02 |
| Last Modified: | 2013-05-14 |
| Downloads: | 4 View Download Statistics |
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