eCite Digital Repository
Systems genetics of the nuclear factor-κB signal transduction network. I. Detection of several quantitative trait loci potentially relevant to aging
Citation
Diego, VP and Curran, JE and Charlesworth, J and Peralta, JM and Voruganti, VS and Cole, SA and Dyer, TD and Johnson, MP and Moses, EK and Goring, HHH and Williams, JT and Comuzzie, AG and Almasy, L and Blangero, J and Williams-Blangero, S, Systems genetics of the nuclear factor-κB signal transduction network. I. Detection of several quantitative trait loci potentially relevant to aging, Mechanisms of Ageing and Development, 133, (1) pp. 11-19. ISSN 0047-6374 (2012) [Refereed Article]
![]() | PDF Restricted - Request a copy 517Kb |
Copyright Statement
Copyright 2011 Elsevier Ireland Ltd.
DOI: doi:10.1016/j.mad.2011.11.007
Abstract
A theory of aging holds that senescence is caused by a dysregulated nuclear factor kappa B (NF-κB) signal
transduction network (STN). We adopted a systems genetics approach in our study of the NF-κB STN.
Ingenuity Pathways Analysis (IPA) was used to identify gene/gene product interactions between NF-κB
and the genes in our transcriptional profiling array. Principal components factor analysis (PCFA) was
performed on a sub-network of 19 genes, including two initiators of the toll-like receptor (TLR) pathway,
myeloid differentiation primary response gene (88) (MyD88) and TIR (Toll/interleukin-1 receptor)-
domain-containing adapter-inducing interferon-β (TRIF). TLR pathways are either MyD88-dependent or
TRIF-dependent. Therefore, we also performed PCFA on a subset excluding the MyD88 transcript, and on
another subset excluding two TRIF transcripts. Using linkage analysis we found that each set gave rise to
at least one factor with a logarithm of the odds (LOD) score greater than 3, two on chromosome 15 at
15q12 and 15q22.2, and another two on chromosome 17 at 17p13.3 and 17q25.3. We also found several
suggestive signals (2 < LOD score < 3) at 1q32.1, 1q41, 2q34, 3q23, and 7p15.3. We are currently
examining potential associations with single nucleotide polymorphisms within the 1-LOD intervals of
our linkage signals.
Item Details
Item Type: | Refereed Article |
---|---|
Keywords: | nuclear factor kappa B, gene expression network, principal components factor analysis, linkage analysis, systems genetics |
Research Division: | Mathematical Sciences |
Research Group: | Statistics |
Research Field: | Biostatistics |
Objective Division: | Health |
Objective Group: | Specific population health (excl. Indigenous health) |
Objective Field: | Health related to ageing |
UTAS Author: | Charlesworth, J (Dr Jac Charlesworth) |
ID Code: | 77521 |
Year Published: | 2012 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2012-04-24 |
Last Modified: | 2017-11-06 |
Downloads: | 0 |
Repository Staff Only: item control page