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A review of the pharmacobiotic regulation of gastrointestinal inflammation by probiotics, commensal bacteria and prebiotics


Vitetta, L and Briskey, D and Hayes, E and Shing, C and Peake, J, A review of the pharmacobiotic regulation of gastrointestinal inflammation by probiotics, commensal bacteria and prebiotics, Inflammopharmacology: Experimental and Clinical Studies, 20, (5) pp. 251-266. ISSN 0925-4692 (2012) [Refereed Article]

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Copyright Statement

Copyright 2012 Springer Basel AG

DOI: doi:10.1007/s10787-012-0126-8


The idea that microbes induce disease has steered medical research toward the discovery of antibacterial products for the prevention and treatment of microbial infections. The twentieth century saw increasing dependency on antimicrobials as mainline therapy accentuating the notion that bacterial interactions with humans were to be avoided or desirably controlled. The last two decades, though, have seen a refocusing of thinking and research effort directed towards elucidating the critical inter-relationships between the gut microbiome and its host that control health/wellness or disease. This research has redefined the interactions between gut microbes and vertebrates, now recognizing that the microbial active cohort and its mammalian host have shared co-evolutionary metabolic interactions that span millennia. Microbial interactions in the gastrointestinal tract provide the necessary cues for the development of regulated pro- and anti-inflammatory signals that promotes immunological tolerance, metabolic regulation and other factors which may then control local and extraintestinal inflammation. Pharmacobiotics, using nutritional and functional food additives to regulate the gut microbiome, will be an exciting growth area of therapeutics, developing alongside an increased scientific understanding of gutmicrobiome symbiosis in health and disease.

Item Details

Item Type:Refereed Article
Keywords:Inflammation, Gastrointestinal, Probiotics, Bacteria, Symbiotics
Research Division:Health Sciences
Research Group:Sports science and exercise
Research Field:Sports science and exercise not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Shing, C (Dr Cecilia Kitic)
ID Code:77246
Year Published:2012
Deposited By:Health Sciences A
Deposited On:2012-03-22
Last Modified:2018-01-31
Downloads:12 View Download Statistics

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