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Pressure-assisted electrokinetic supercharging for the enhancement of non-steroidal anti-inflammatory drugs
Citation
Meighan, MM and Dawod, M and Guijt, RM and Hayes, MA and Breadmore, MC, Pressure-assisted electrokinetic supercharging for the enhancement of non-steroidal anti-inflammatory drugs, Journal of Chromatography A, 1218, (38) pp. 6750-6755. ISSN 0021-9673 (2011) [Refereed Article]
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DOI: doi:10.1016/j.chroma.2011.07.044
Abstract
Electrokinetic supercharging (EKS) combines field-amplified sample injection with transient isotachophoresis (tITP) to create a powerful on-line preconcentration technique for capillary electrophoresis. In this work, EKS is enhanced with a positive pressure (pressure-assisted EKS, or PA-EKS) during injection to improve stacking of non-steroidal anti-inflammatory drugs (NSAIDs). Several parameters, including buffer composition and concentration, terminating electrolyte, organic modifier, and injection voltage and injection time of both terminating electrolyte and sample were optimized. Detection limits for seven NSAIDs were determined and an enhancement in sensitivity of almost 50,000-fold was obtained. The PA-EKS method has the potential to be a simple MS compatible preconcentration method to improve the sensitivity of CE.
Item Details
Item Type: | Refereed Article |
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Research Division: | Chemical Sciences |
Research Group: | Analytical chemistry |
Research Field: | Separation science |
Objective Division: | Expanding Knowledge |
Objective Group: | Expanding knowledge |
Objective Field: | Expanding knowledge in the chemical sciences |
UTAS Author: | Dawod, M (Mr Mohamed Dawod) |
UTAS Author: | Guijt, RM (Dr Rosanne Guijt) |
UTAS Author: | Breadmore, MC (Professor Michael Breadmore) |
ID Code: | 76892 |
Year Published: | 2011 |
Web of Science® Times Cited: | 22 |
Deposited By: | Chemistry |
Deposited On: | 2012-03-14 |
Last Modified: | 2013-01-21 |
Downloads: | 0 |
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