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Centrifugally-driven microfluidic compact discs (l-CDs) have attracted significant interest within the analytical science community in the past decade, with the primary focus on the potential of such platforms for performing parallel and/or multiplex biological assays and further application in biomedical diagnostics. More recently, l-CD-based devices were also applied to environmental analysis as platforms for multi-sample extraction and transportation, prior to off-disc analysis in the laboratory. This review critically summarizes recent developments in l-CD platforms for sample extraction, preconcentration, fractionation and purification in bioanalytical and environmental applications. We also summarize the common methods employed in the fabrication of l-CD platforms. Further, we discuss preparation of stationary phases in microfluidic channels embedded in l-CDs, as applications of l-CDs in sample extraction are generally based on enclosed series of extraction phases and microcolumns.

Item Type:	Refereed Article
Keywords:	Centrifugally-driven microextraction, Electrophoretic separation, Fractionation, Lab-on-a-disc, Microfluidic compact disc (l-CD), Monolithic stationary phase, Packed stationary phase, Preconcentration, Purification, Sample extraction
Research Division:	Chemical Sciences
Research Group:	Analytical Chemistry
Research Field:	Separation Science
Objective Division:	Expanding Knowledge
Objective Group:	Expanding Knowledge
Objective Field:	Expanding Knowledge in the Mathematical Sciences
Author:	Paull, B (Professor Brett Paull)
ID Code:	76747
Year Published:	2011
Web of Science® Times Cited:	19
Deposited By:	Chemistry
Deposited On:	2012-03-13
Last Modified:	2012-05-11
Downloads:	9 View Download Statistics