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Centrifugally-driven sample extraction, preconcentration and purification in microfluidic compact discs
journal contribution
posted on 2023-05-17, 11:06 authored by Vazquez, M, Brabazon, D, Shang, F, Omamogho, JO, Glennon, JD, Brett PaullBrett PaullCentrifugally-driven microfluidic compact discs (l-CDs) have attracted significant interest within the analytical science community in the past decade, with the primary focus on the potential of such platforms for performing parallel and/or multiplex biological assays and further application in biomedical diagnostics. More recently, l-CD-based devices were also applied to environmental analysis as platforms for multi-sample extraction and transportation, prior to off-disc analysis in the laboratory. This review critically summarizes recent developments in l-CD platforms for sample extraction, preconcentration, fractionation and purification in bioanalytical and environmental applications. We also summarize the common methods employed in the fabrication of l-CD platforms. Further, we discuss preparation of stationary phases in microfluidic channels embedded in l-CDs, as applications of l-CDs in sample extraction are generally based on enclosed series of extraction phases and microcolumns.
History
Publication title
Trends in Analytical ChemistryVolume
30Issue
10Pagination
1575-1586ISSN
0165-9936Department/School
School of Natural SciencesPublisher
Elsevier Science LondonPlace of publication
84 Theobalds Rd, London, England, Wc1X 8RrRights statement
The definitive version is available at http://www.sciencedirect.comRepository Status
- Restricted