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Centrifugally-driven sample extraction, preconcentration and purification in microfluidic compact discs


Vazquez, M and Brabazon, D and Shang, F and Omamogho, JO and Glennon, JD and Paull, B, Centrifugally-driven sample extraction, preconcentration and purification in microfluidic compact discs, Trends in Analytical Chemistry, 30, (10) pp. 1575-1586. ISSN 0165-9936 (2011) [Refereed Article]

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DOI: doi:10.1016/j.trac.2011.07.007


Centrifugally-driven microfluidic compact discs (l-CDs) have attracted significant interest within the analytical science community in the past decade, with the primary focus on the potential of such platforms for performing parallel and/or multiplex biological assays and further application in biomedical diagnostics. More recently, l-CD-based devices were also applied to environmental analysis as platforms for multi-sample extraction and transportation, prior to off-disc analysis in the laboratory. This review critically summarizes recent developments in l-CD platforms for sample extraction, preconcentration, fractionation and purification in bioanalytical and environmental applications. We also summarize the common methods employed in the fabrication of l-CD platforms. Further, we discuss preparation of stationary phases in microfluidic channels embedded in l-CDs, as applications of l-CDs in sample extraction are generally based on enclosed series of extraction phases and microcolumns.

Item Details

Item Type:Refereed Article
Keywords:Centrifugally-driven microextraction, Electrophoretic separation, Fractionation, Lab-on-a-disc, Microfluidic compact disc (l-CD), Monolithic stationary phase, Packed stationary phase, Preconcentration, Purification, Sample extraction
Research Division:Chemical Sciences
Research Group:Analytical chemistry
Research Field:Separation science
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the mathematical sciences
UTAS Author:Paull, B (Professor Brett Paull)
ID Code:76747
Year Published:2011
Web of Science® Times Cited:23
Deposited By:Chemistry
Deposited On:2012-03-13
Last Modified:2012-05-11
Downloads:9 View Download Statistics

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