eCite Digital Repository
The Arabidopsis peptide kiss of death is an inducer of programmed cell death
Citation
Blanvillain, R and Young, B and Cai, Y and Hecht, V and Varoquaux, F and Delorme, V and Lancelin, J and Delseny, M and Gallois, P, The Arabidopsis peptide kiss of death is an inducer of programmed cell death, The EMBO Journal: (European Molecular Biology Organization), 30, (Feb) pp. 1173-1183. ISSN 0261-4189 (2011) [Refereed Article]
![]() | PDF Restricted - Request a copy 1Mb |
Copyright Statement
Copyright 2011 European Molecular Biology Organization
DOI: doi:10.1038/emboj.2011.14
Abstract
Programmed cell death (PCD) has a key role in defence
and development of all multicellular organisms. In plants,
there is a large gap in our knowledge of the molecular
machinery involved at the various stages of PCD,
especially the early steps. Here, we identify kiss of death
(KOD) encoding a 25-amino-acid peptide that activates a
PCD pathway in Arabidopsis thaliana. Two mutant alleles
of KOD exhibited a reduced PCD of the suspensor, a single
file of cells that support embryo development, and a
reduced PCD of root hairs after a 551C heat shock. KOD
expression was found to be inducible by biotic and abiotic
stresses. Furthermore, KOD expression was sufficient to
cause death in leaves or seedlings and to activate caspaselike
activities. In addition, KOD-induced PCD required
light in leaves and was repressed by the PCD-suppressor
genes AtBax inhibitor 1 and p35. KOD expression resulted
in depolarization of the mitochondrial membrane, placing
KOD above mitochondria dysfunction, an early step in
plant PCD. A KODHGFP fusion, however, localized in the
cytosol of cells and not mitochondria.
Item Details
Item Type: | Refereed Article |
---|---|
Keywords: | Programmed cell death, PCD, BAX inhibitor 1, caspase-like, ebryogenesis, p35, KOD expresssion |
Research Division: | Biological Sciences |
Research Group: | Biochemistry and cell biology |
Research Field: | Cell development, proliferation and death |
Objective Division: | Expanding Knowledge |
Objective Group: | Expanding knowledge |
Objective Field: | Expanding knowledge in the biological sciences |
UTAS Author: | Hecht, V (Dr Valerie Hecht) |
ID Code: | 76676 |
Year Published: | 2011 |
Web of Science® Times Cited: | 49 |
Deposited By: | Plant Science |
Deposited On: | 2012-03-09 |
Last Modified: | 2017-11-02 |
Downloads: | 0 |
Repository Staff Only: item control page