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Seronegative spondyloarthritis


Zochling, J and Smith, EUR, Seronegative spondyloarthritis, Best Practice & Research: Clinical Rheumatology, 24, (6) pp. 747-756. ISSN 1532-1770 (2011) [Refereed Article]

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Copyright Statement

Copyright 2011 Elsevier Ltd.

DOI: doi:10.1016/j.berh.2011.02.002


Seronegative spondyloarthritis (SpA) is a group of inflammatory rheumatic diseases with common clinical and aetiological features, including axial and peripheral inflammatory arthritis, enthesitis, extra-articular manifestations and a close link to the presence of the human leucocyte antigen (HLA)-B27 epitope. Ankylosing spondylitis is the most common of the SpA diseases, with prevalence in the Caucasian population ranging between 0.15% and 1.8%, generally higher in populations with a higher background prevalence of HLA-B27 positivity. Incidence has been estimated between 0.49 (Japan) and 10 (Norway) per 100,000. The prevalence of psoriatic arthritis ranges from 0.02% to 0.2%, and the incidence in the normal population is 7.2 per 100,000 per year. In patients with existing psoriasis, the prevalence of psoriatic arthritis rises to 6-42%. The prevalence of reactive arthritis is dependent on the background incidence of gastrointestinal or genitourinary infections; incidence has been described as up to 30-40 per 100,000. SpA symptoms are present in up to 50% of patients with inflammatory bowel disease.

Item Details

Item Type:Refereed Article
Keywords:spondyloarthritis; ankylosing spondylitis; psoriatic arthritis; reactive arthritis; prevalence; epidemiology
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Rheumatology and arthritis
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Zochling, J (Dr Jane Zochling)
ID Code:76596
Year Published:2011
Web of Science® Times Cited:56
Deposited By:Menzies Institute for Medical Research
Deposited On:2012-03-08
Last Modified:2018-03-21

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