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A longitudinal study of the association between dietary factors, serum lipids, and bone marrow lesions of the knee

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Dore, D and De Hoog, J and Giles, G and Ding, C and Cicuttini, F and Jones, G, A longitudinal study of the association between dietary factors, serum lipids, and bone marrow lesions of the knee, Arthritis Research & Therapy, 14, (1) Article R13. ISSN 1478-6362 (2012) [Refereed Article]


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Licensed under Creative Commons Attribution 2.0 Generic (CC BY 2.0) http://creativecommons.org/licenses/by/2.0/

DOI: doi:10.1186/ar3689

Abstract

Introduction: Bone marrow lesions (BMLs) play an important role in knee osteoarthritis, but their etiology is not well understood. The aim of this longitudinal study was to describe the association between dietary factors, serum lipids, and BMLs.

Methods: In total, 394 older men and women (mean age, 63 years; range, 52 to 79) were measured at baseline and approximately 2.7 years later. BMLs were determined by using T2-weighted fat-saturation magnetic resonance imaging (MRI) by measuring the maximal area of the lesion. Nutrient intake (total energy, fat, carbohydrate, protein, and sugar) and serum lipids were assessed at baseline.

Results: Cross-sectionally, dietary factors and lipids were not significantly associated with BMLs. Energy, carbohydrate, and sugar intake (but not fat) were positively associated with a change in BML size (‚ = 15.44 to 19.27 mm2 per 1 SD increase; all P < 0.05). High-density lipoprotein (HDL) cholesterol tended to be negatively associated with BML change (‚ = -11.66 mm2 per 1 SD increase; P = 0.088).

Conclusions: Energy, carbohydrate, and sugar intake may be risk factors for BML development and progression. HDL cholesterol seems protective against BMLs. These results suggest that macronutrients and lipids may be important in BML etiology and that dietary modification may alter BML natural history.

Item Details

Item Type:Refereed Article
Keywords:nutrition examination survey, middle-aged adults, cartilage volume, fatty acids, radiographic features, prospective chohort, national health, risk factors, US adults, osteoarthritis
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Dore, D (Dr Dawn Aitken)
Author:De Hoog, J (Mr Jonathon De Hoog)
Author:Ding, C (Professor Chang-Hai Ding)
Author:Jones, G (Professor Graeme Jones)
ID Code:76461
Year Published:2012
Funding Support:National Health and Medical Research Council (1045415)
Web of Science® Times Cited:18
Deposited By:Menzies Institute for Medical Research
Deposited On:2012-03-06
Last Modified:2017-11-02
Downloads:299 View Download Statistics

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