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Epstein-Barr virus and multiple sclerosis

Citation

Lucas, RM and Hughes, AM and Lay, MLJ and Ponsonby, AL and Dwyer, DE and Taylor, BV and Pender, MP, Epstein-Barr virus and multiple sclerosis, Journal of Neurology, Neurosurgery and Psychiatry, 82, (10) pp. 1142-1148. ISSN 0022-3050 (2011) [Refereed Article]


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Copyright Statement

Copyright 2011 British Medical Journal Publishing Group

DOI: doi:10.1136/jnnp-2011-300174

Abstract

This review of the considerable evidence linking EpsteineBarr virus (EBV) infection to risk and disease progression in multiple sclerosis (MS) builds on the background to the virus and its interactions with the human host available in the online supplement (see supplement, available online only). The evidence for a similarity in the geographic patterns of occurrence of MS and EBV infection (with infectious mononucleosis or EBV specific serology used as surrogate markers), when reviewed critically, is very limited. There is strong evidence however that people with MS are more likely to report a past history of infectious mononucleosis (thought to represent initial EBV infection at an older age), and higher titres of EBV specific antibodies are associated with an increased risk of developing MS. Elevated levels of the latter are apparent many years before MS onset (compared with non-MS controls) and there is a doseeresponse relationship between MS risk and antibody titre, with antibodies to the EBV nuclear antigen-1 particularly important. The evidence in relation to EBV DNA load in blood or CSF is conflicting, as is that in relation to T cell responses to EBV. Several hypotheses that have been proposed to explain the links between EBV and MS risk are reviewed and gaps requiring further research are identified.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Central Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Taylor, BV (Professor Bruce Taylor)
ID Code:76380
Year Published:2011
Web of Science® Times Cited:46
Deposited By:Menzies Institute for Medical Research
Deposited On:2012-03-06
Last Modified:2017-11-02
Downloads:1 View Download Statistics

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