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Effectiveness of H1N1/09 monovalent and trivalent influenza vaccines against hospitalization with laboratory-confirmed H1N1/09 influenza in Australia: A test-negative case control study
journal contribution
posted on 2023-05-17, 10:48 authored by Cheng, AC, Kotsimbos, T, Kelly, HA, Irving, LB, Bowler, SD, Brown, SGA, Holmes, M, Jenkins, CR, Thompson, P, Simpson, G, Wood-Baker, R, Senanayake, SN, Brady, SJ, Paterson, DL, Wark, PA, Upham, JW, Korman, TM, Dwyer, DE, Waterer, GW, Kelly, PMWe aimed to estimate the effectiveness of H1N1/09 containing influenza vaccines against hospitalization from influenza in Australia. We performed a test-negative case control study in patients hospitalized in 15 sentinel Australian hospitals between March and November 2010, comparing influenza vaccination (H1N1/09 monovalent or 2010 seasonal trivalent) in hospitalized patients with PCR-confirmed influenza compared to PCR-negative controls. Between March and November 2010, 1169 hospitalized patients were tested for suspected influenza, of which influenza vaccine status was ascertained in 165/238 patients with H1N1/09 influenza, 40/64 with seasonal influenza and 558/867 test negative controls; 24% of H1N1/09 cases, 43% of seasonal influenza cases and 54% of controls were vaccinated. VE against hospitalisation with H1N1/09 influenza after adjusting for age, medical comorbidities and pregnancy status was estimated at 49% (95% CI: 13%, 70%). Influenza vaccination was associated with a reduction in hospitalisation caused by H1N1/09 influenza in the 2010 southern hemisphere winter season.
History
Publication title
VaccineVolume
29Issue
43Pagination
7320-7325ISSN
0264-410XDepartment/School
Menzies Institute for Medical ResearchPublisher
Elsevier Sci LtdPlace of publication
The Boulevard, Langford Lane, Kidlington, Oxford, England, Oxon, Ox5 1GbRights statement
The definitive version is available at http://www.sciencedirect.comRepository Status
- Restricted