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Revisiting the role of acetylcholinesterase in Alzheimer's disease: cross-talk with P-tau and β-amyloid

Citation

Garcia-Ayllon, MS and Small, DH and Avila, J and Saez-Valero, J, Revisiting the role of acetylcholinesterase in Alzheimer's disease: cross-talk with P-tau and β-amyloid, Frontiers in Molecular Neuroscience, 4 Article 22. ISSN 1662-5099 (2011) [Refereed Article]


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Licensed under Creative Commons Attribution 3.0 Unported (CC BY 3.0) http://creativecommons.org/licenses/by/3.0/

DOI: doi:10.3389/fnmol.2011.00022

Abstract

A common feature in the Alzheimer's disease (AD) brain is the presence of acetylcholinesterase (AChE) which is commonly associated with â-amyloid plaques and neurofibrillary tangles (NFT). Although our understanding of the relationship between AChE and the pathological features of AD is incomplete, increasing evidence suggests that both â-amyloid protein (Aâ) and abnormally hyperphosphorylated tau (P-tau) can influence AChE expression. We also review recent findings which suggest the possible role of AChE in the development of a vicious cycle of Aâ and P-tau dysregulation and discuss the limited and temporary effect of therapeutic intervention with AChE inhibitors.

Item Details

Item Type:Refereed Article
Keywords:acetylcholinesterase, B-amyloid, presenilin1, P-tau, Alzheimer’sdisease
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurosciences not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Neurodegenerative Disorders Related to Ageing
Author:Small, DH (Professor David Small)
ID Code:76158
Year Published:2011
Deposited By:Menzies Institute for Medical Research
Deposited On:2012-02-29
Last Modified:2017-12-07
Downloads:230 View Download Statistics

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