Soltani, A and Ewe, YP and Lim, ZS and Sohal, SS and Reid, D and Weston, S and Wood-Baker, R and Walters, EH, Mast cells in COPD airways: relationship to bronchodilator responsiveness and angiogenesis, European Respiratory Journal, 39, (6) pp. 1361-1367. ISSN 1399-3003 (2012) [Refereed Article]
Copyright 2011 by the European Respiratory Society.
We have investigated whether mast cells are associated with bronchodilator responsiveness and airway vascular changes in chronic obstructive pulmonary disease (COPD) airways. We have previously shown that the reticular basement membrane is hypervascular and the lamina propria is hypovascular in COPD.
Bronchial biopsies from 32 COPD subjects, 15 smokers with normal lung function and 17 controls, were immunostained for factor VIII, mast cell tryptase and chymase antibodies. Mast cells in the airway smooth muscle, the reticular basement membrane and the underlying lamina propria were quantitated.
41% of COPD subjects had significant bronchodilator responsiveness, but this was not related to smooth muscle mast cell numbers. The reticular basement membrane had greater mast cell density in all groups compared with controls (p = 0.01). In this compartment, perivascular mast cell density was related to hypervascularity. Lamina propria mast cell density was increased only in COPD (p = 0.05). Perivascular mast cell density in the lamina propria was not related to its decreased vessel density.
Bronchodilator responsiveness in COPD is not related to large airway smooth muscle mast cells of either type; both reticular basement membrane and lamina propria mast cells are increased in COPD patients, and perivascular mast cells may be involved in increased angiogenesis in the reticular basement membrane.
|Item Type:||Refereed Article|
|Keywords:||Airway remodelling, airway vessels, bronchodilator responsiveness (BDR), chronic obstructive pulmonary disease (COPD), mast cells|
|Research Division:||Medical and Health Sciences|
|Research Group:||Cardiorespiratory Medicine and Haematology|
|Research Field:||Respiratory Diseases|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Respiratory System and Diseases (incl. Asthma)|
|Author:||Soltani, A (Dr Amir Soltani Abhari)|
|Author:||Ewe, YP (Mr Yean Ewe)|
|Author:||Lim, ZS (Mr Zhen Lim)|
|Author:||Sohal, SS (Dr Sukhwinder Sohal)|
|Author:||Weston, S (Mr Steven Weston)|
|Author:||Wood-Baker, R (Professor Richard Wood-Baker)|
|Author:||Walters, EH (Professor Haydn Walters)|
|Year Published:||2012 (online first 2011)|
|Web of Science® Times Cited:||9|
|Deposited By:||Menzies Institute for Medical Research|
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