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APOE Genotype and Cardio-Respiratory Fitness Interact to Determine Adiposity in 8-Year-Old Children from the Tasmanian Infant Health Survey
Citation
Ellis, JA and Ponsonby, AL and Pezic, A and Williamson, E and Cochrane, JA and Dickinson, JL and Dwyer, T, APOE Genotype and Cardio-Respiratory Fitness Interact to Determine Adiposity in 8-Year-Old Children from the Tasmanian Infant Health Survey, PL o S One, 6, (11) Article e26679. ISSN 1932-6203 (2011) [Refereed Article]
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Copyright Statement
Licensed under Creative Commons Attribution 2.5 Generic (CC BY 2.5) http://creativecommons.org/licenses/by/2.5/
DOI: doi:10.1371/journal.pone.0026679
Abstract
APOE plays a well established role in lipid metabolism. Animal model evidence suggests APOE may also be associated with
adiposity, but this has not been thoroughly investigated in humans. We measured adiposity (BMI, truncal fat mass, waist
circumference), physical activity (PA), cardiorespiratory fitness and APOE genotype (E2, E3, E4) in 292 8-year-old children
from the Tasmanian Infant Health Survey (TIHS), an Australian population-based prospective birth cohort. Our aims were to
examine the association of APOE with child adiposity, and to examine the interplay between this association and other
measured factors. We found that APOE was associated with child lipid profiles. APOE was also associated with child adiposity
measures. The association was E4 allele-specific, with adiposity lower in the E4-containing group (BMI: Mean difference
-0.90 kg/m2; 95% confidence intervals (CI) -1.51, -0.28; p = 0.004). The association of APOE4 with lower BMI differed by fitness
status (difference in effect p = 0.002), and was more evident among the less fit (mean difference -1.78 kg/m2; 95% CI -2.74,
-0.83; p,0.001). Additionally, associations between BMI and lipids were only apparent in those of lower fitness who did not
carry APOE4. Similar overall findings were observed when truncal fat mass and waist circumference were used as alternative
adiposity measures. APOE4 and cardiorespitatory fitness could interact to influence child adiposity. In studies addressing the
genetic determinants of childhood obesity, the context of child fitness should also be taken into account.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Paediatrics |
| Research Field: | Paediatrics not elsewhere classified |
| Objective Division: | Health |
| Objective Group: | Public health (excl. specific population health) |
| Objective Field: | Health status (incl. wellbeing) |
| UTAS Author: | Ponsonby, AL (Professor Anne Ponsonby) |
| UTAS Author: | Cochrane, JA (Mrs Jennifer Cochrane) |
| UTAS Author: | Dickinson, JL (Professor Joanne Dickinson) |
| UTAS Author: | Dwyer, T (Professor Terry Dwyer) |
| ID Code: | 75974 |
| Year Published: | 2011 |
| Web of Science® Times Cited: | 9 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2012-02-21 |
| Last Modified: | 2017-10-06 |
| Downloads: | 612 View Download Statistics |
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