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Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study


Kote-Jarai, Z and Al Olama, AA and Giles, GG and Severi, G and Schleutker, J and Weischer, M and Campa, D and Riboli, E and Key, T and Gronberg, H and Hunter, DJ and Kraft, P and Thun, MJ and Ingles, S and Chanock, S and Albanes, D and Hayes, RB and Neal, DE and Hamdy, FC and Donovan, JL and Pharoah, P and Schumacher, F and Henderson, BE and Stanford, JL and Ostrander, EA and Sorensen, KD and Dork, T and Andriole, G and Dickinson, JL and Cybulski, C and Lubinski, J and Spurdle, A and Clements, JA and Chambers, S and Aitken, J and Gardiner, RAF and Thibodeau, SN and Schaid, D and John, EM and Maier, C and Vogel, W and Cooney, KA and Park, JY and Cannon-Albright, L and Brenner, H and Habuchi, T and Zhang, HW and Lu, YJ and Kaneva, R and Muir, K and Benlloch, S and Leongamornlert, DA and Saunders, EJ and Tymrakiewicz, M and Mahmud, N and Guy, M and O'Brien, LT and Wilkinson, RA and Hall, AL and Sawyer, EJ and Dadaev, T and Morrison, J and Dearnaley, DP and Horwich, A and Huddart, RA and Khoo, VS and Parker, CC and Van As, N and Woodhouse, CJ and Thompson, A and Christmas, T and Ogden, C and Cooper, CS and Lophatonanon, A and Southey, MC and Hopper, JL and English, DR and Wahlfors, T and Tammela, TLJ and Klarskov, P and Nordestgaard, BG and Roder, MA and Tybjaerg-Hansen, A and Bojesen, SE and Travis, R and Canzian, F and Kaaks, R and Wiklund, F and Aly, M and Lindstrom, S and Diver, WR and Gapstur, S and Stern, MC and Corral, R and Virtamo, J and Cox, A and Haiman, CA and Le Marchand, L and Fitzgerald, L and Kolb, S and Kwon, EM and Karyadi, DM and Orntoft, TF and Borre, M and Meyer, A and Serth, J and Yeager, M and Berndt, SI and Marthick, JR and Patterson, B and Wokolorczyk, D and Batra, J and Lose, F and McDonnell, SK and Joshi, AD and Shahabi, A and Rinckleb, AE and Ray, A and Sellers, TA and Lin, HY and Stephenson, RA and Farnham, J and Muller, H and Rothenbacher, D and Tsuchiya, N and Narita, S and Cao, GW and Slavov, C and Mitev, V and Easton, DF and Eeles, RA, Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study, Nature Genetics, 43, (8) pp. 785-791. ISSN 1061-4036 (2011) [Refereed Article]

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ฉ 2011 Nature Publishing Group

DOI: doi:10.1038/ng.882


Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. We conducted a multi-stage genome-wide association study for PrCa and previously reported the results of the first two stages, which identified 16 PrCa susceptibility loci. We report here the results of stage 3, in which we evaluated 1,536 SNPs in 4,574 individuals with prostate cancer (cases) and 4,164 controls. We followed up ten new association signals through genotyping in 51,311 samples in 30 studies from the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium. In addition to replicating previously reported loci, we identified seven new prostate cancer susceptibility loci on chromosomes 2p11, 3q23, 3q26, 5p12, 6p21, 12q13 and Xq12 (P = 4.0 ื 10−8 to P = 2.7 ื 10−24). We also identified a SNP in TERT more strongly associated with PrCa than that previously reported. More than 40 PrCa susceptibility loci, explaining ~25% of the familial risk in this disease, have now been identified.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Oncology and carcinogenesis
Research Field:Cancer genetics
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Dickinson, JL (Professor Joanne Dickinson)
UTAS Author:Fitzgerald, L (Dr Liesel Fitzgerald)
UTAS Author:Marthick, JR (Mr James Marthick)
UTAS Author:Patterson, B (Dr Briony Patterson)
ID Code:75965
Year Published:2011
Web of Science® Times Cited:222
Deposited By:Menzies Institute for Medical Research
Deposited On:2012-02-21
Last Modified:2015-11-06

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