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Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study

journal contribution
posted on 2023-05-17, 10:31 authored by Kote-Jarai, Z, Al Olama, AA, Giles, GG, Severi, G, Schleutker, J, Weischer, M, Campa, D, Riboli, E, Key, T, Gronberg, H, Hunter, DJ, Kraft, P, Thun, MJ, Ingles, S, Chanock, S, Albanes, D, Hayes, RB, Neal, DE, Hamdy, FC, Donovan, JL, Pharoah, P, Schumacher, F, Henderson, BE, Stanford, JL, Ostrander, EA, Sorensen, KD, Dork, T, Andriole, G, Joanne DickinsonJoanne Dickinson, Cybulski, C, Lubinski, J, Spurdle, A, Clements, JA, Chambers, S, Aitken, J, Gardiner, RAF, Thibodeau, SN, Schaid, D, John, EM, Maier, C, Vogel, W, Cooney, KA, Park, JY, Cannon-Albright, L, Brenner, H, Habuchi, T, Zhang, HW, Lu, YJ, Kaneva, R, Muir, K, Benlloch, S, Leongamornlert, DA, Saunders, EJ, Tymrakiewicz, M, Mahmud, N, Guy, M, O'Brien, LT, Wilkinson, RA, Hall, AL, Sawyer, EJ, Dadaev, T, Morrison, J, Dearnaley, DP, Horwich, A, Huddart, RA, Khoo, VS, Parker, CC, Van As, N, Woodhouse, CJ, Thompson, A, Christmas, T, Ogden, C, Cooper, CS, Lophatonanon, A, Southey, MC, Hopper, JL, English, DR, Wahlfors, T, Tammela, TLJ, Klarskov, P, Nordestgaard, BG, Roder, MA, Tybjaerg-Hansen, A, Bojesen, SE, Travis, R, Canzian, F, Kaaks, R, Wiklund, F, Aly, M, Lindstrom, S, Diver, WR, Gapstur, S, Stern, MC, Corral, R, Virtamo, J, Cox, A, Haiman, CA, Le Marchand, L, Liesel FitzgeraldLiesel Fitzgerald, Kolb, S, Kwon, EM, Karyadi, DM, Orntoft, TF, Borre, M, Meyer, A, Serth, J, Yeager, M, Berndt, SI, James MarthickJames Marthick, Patterson, B, Wokolorczyk, D, Batra, J, Lose, F, McDonnell, SK, Joshi, AD, Shahabi, A, Rinckleb, AE, Ray, A, Sellers, TA, Lin, HY, Stephenson, RA, Farnham, J, Muller, H, Rothenbacher, D, Tsuchiya, N, Narita, S, Cao, GW, Slavov, C, Mitev, V, Easton, DF, Eeles, RA
Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. We conducted a multi-stage genome-wide association study for PrCa and previously reported the results of the first two stages, which identified 16 PrCa susceptibility loci. We report here the results of stage 3, in which we evaluated 1,536 SNPs in 4,574 individuals with prostate cancer (cases) and 4,164 controls. We followed up ten new association signals through genotyping in 51,311 samples in 30 studies from the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium. In addition to replicating previously reported loci, we identified seven new prostate cancer susceptibility loci on chromosomes 2p11, 3q23, 3q26, 5p12, 6p21, 12q13 and Xq12 (P = 4.0 × 10−8 to P = 2.7 × 10−24). We also identified a SNP in TERT more strongly associated with PrCa than that previously reported. More than 40 PrCa susceptibility loci, explaining ~25% of the familial risk in this disease, have now been identified.

History

Publication title

Nature Genetics

Volume

43

Issue

8

Pagination

785-791

ISSN

1061-4036

Department/School

Menzies Institute for Medical Research

Publisher

Nature Publishing Group

Place of publication

345 Park Ave South, New York, USA, Ny, 10010-1707

Rights statement

© 2011 Nature Publishing Group

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  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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    University Of Tasmania

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    In Copyright

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