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Prevalence of chronic ocular diseases in a genetic isolate: The Norfolk Island Eye Study (NIES)

Citation

Sherwin, JC and Kearns, LS and Hewitt, AW and Ma, Y and Kelly, J and Griffiths, LR and Mackey, DA, Prevalence of chronic ocular diseases in a genetic isolate: The Norfolk Island Eye Study (NIES), Ophthalmic Epidemiology, 18, (2) pp. 61-71. ISSN 0928-6586 (2011) [Refereed Article]

Copyright Statement

Copyright 2011 Informa UK Ltd

DOI: doi:10.3109/09286586.2010.545933

Abstract

Purpose: Over 40% of the permanent population of Norfolk Island possesses a unique genetic admixture dating to Pitcairn Island in the late 18th century, with descendents having varying degrees of combined Polynesian and European ancestry. We conducted a population-based study to determine the prevalence and causes of blindness and low vision on Norfolk Island. Methods: All permanent residents of Norfolk Island aged ≥ 15 years were invited to participate. Participants completed a structured questionnaire/interview and underwent a comprehensive ophthalmic examination including slit-lamp biomicroscopy. Results: We recruited 781 people aged ≥ 15, equal to 62% of the permanent population, 44% of whom could trace their ancestry to Pitcairn Island. No one was bilaterally blind. Prevalence of unilateral blindness (visual acuity [VA] < 6/60) in those aged ≥ 40 was 1.5%. Blindness was more common in females (P = 0.049) and less common in people with Pitcairn Island ancestry (P < 0.001). The most common causes of unilateral blindness were age-related macular degeneration (AMD), amblyopia, and glaucoma. Five people had low vision (Best-Corrected VA < 6/18 in better eye), with 4 (80%) due to AMD. People with Pitcairn Island ancestry had a lower prevalence of AMD (P < 0.001) but a similar prevalence of glaucoma to those without Pitcairn Island ancestry. Conclusions: The prevalence of blindness and visual impairment in this isolated Australian territory is low, especially amongst those with Pitcairn Island ancestry. AMD was the most common cause of unilateral blindness and low vision. The distribution of chronic ocular diseases on Norfolk Island is similar to mainland Australian estimates.

Item Details

Item Type:Refereed Article
Keywords:blindness, epidemiology, genetics, glaucoma, macular degeneration, Norfolk Island, Pitcairn Island, population isolates, viual impairment, cardiovascular diease, cataract
Research Division:Medical and Health Sciences
Research Group:Ophthalmology and Optometry
Research Field:Ophthalmology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Hearing, Vision, Speech and Their Disorders
Author:Hewitt, AW (Dr Alex Hewitt)
Author:Mackey, DA (Professor David Mackey)
ID Code:75784
Year Published:2011
Web of Science® Times Cited:7
Deposited By:Medicine (Discipline)
Deposited On:2012-02-16
Last Modified:2017-09-06
Downloads:0

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