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The association between pterygium and conjunctival ultraviolet autofluorescence: The Norfolk Island Eye Study

Citation

Sherwin, JC and Hewitt, AW and Kearns, LS and Griffiths, LR and Mackey, DA and Coroneo, MT, The association between pterygium and conjunctival ultraviolet autofluorescence: The Norfolk Island Eye Study, Acta Ophthalmologica, 91, (4) pp. 363-370. ISSN 1755-3768 (2011) [Refereed Article]


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The definitive published version is available online at: http://www3.interscience.wiley.com/

DOI: doi:10.1111/j.1755-3768.2011.02314.x

Abstract

Purpose: To investigate the association between conjunctival ultraviolet autofluorescence (UVAF), a biomarker of ocular ultraviolet radiation (UVR) exposure, and prevalent pterygium.

Methods: We conducted a cross-sectional study on Norfolk Island, South Pacific. All permanent residents aged ≥15 were invited to participate. Participants completed a sun exposure questionnaire and underwent autorefraction and slit lamp biomicroscope examination. Area of conjunctival UVAF (sum of temporal/nasal area in right and left eyes) was determined using computerized methods. Multivariate logistic and linear regression models were used to estimate the associations with pterygia and UVAF, respectively.

Results: Of 641 participants, 70 people (10.9%) had pterygium in one or both eyes, and prevalence was higher in males (15.0% versus 7.7%, p = 0.003). Significant independent associations with pterygium in any eye were UVAF (per 10 mm2) [odds ratio (OR) 1.16, 95% confidence interval (CI) 1.161.28, p = 0.002], tanning skin phenotype (OR 2.17, 1.203.92, p = 0.010) and spending more than three-quarters of the day outside (OR 2.22, 1.204.09, p = 0.011). Increasing quartile of UVAF was associated with increased risk of pterygium following adjustment of age, sex and time outdoors (pTrend = 0.002). Independent associations with increasing UVAF (per 10 mm2) were decreasing age, time outdoors, skin type and male gender (all p < 0.001). UVAF area correlated well with the duration of outdoor activity (pTrend < 0.001).

Conclusion: Pterygium occurs in approximately one-tenth of Norfolk Islanders. Increasing conjunctival UVAF is associated with prevalent pterygia, confirming earlier epidemiological, laboratory and ray-tracing studies that pterygia are associated with UVR. Protection from the sun should be encouraged to reduce the prevalence of pterygium in the community.

Item Details

Item Type:Refereed Article
Keywords:conjunctiva, epidemiology, pterygium, sunlight, ultraviolet radiation
Research Division:Medical and Health Sciences
Research Group:Ophthalmology and Optometry
Research Field:Ophthalmology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Hearing, Vision, Speech and Their Disorders
Author:Hewitt, AW (Dr Alex Hewitt)
Author:Mackey, DA (Professor David Mackey)
ID Code:75755
Year Published:2011
Web of Science® Times Cited:23
Deposited By:Medicine (Discipline)
Deposited On:2012-02-15
Last Modified:2017-11-06
Downloads:0

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