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Intermittent high-dose vitamin D corrects vitamin D deficiency in adolescents: a pilot study
journal contribution
posted on 2023-05-17, 10:18 authored by Carnes, J, Quinn, S, Mark NelsonMark Nelson, Graeme JonesGraeme Jones, Tania WinzenbergTania WinzenbergWe aimed to assess the safety and efficacy of high-dose intermittent vitamin D supplementation in adolescents. Twenty-two healthy adolescents with serum 25 hydroxy-vitamin D (25-OHD) of 12.5–50 nmol/l were randomised to receive 300 000 IU or 150 000 IU of vitamin D3, or placebo orally 6-monthly for 1 year. At 12 months, the average vitamin D levels for the 300 000 IU, 150 000 IU and placebo groups were 63.0, 41.1 and 35.8 nmol/l, respectively, (P = 0.004 for difference between 300 000 IU group and placebo after adjustment for age, sex and seasonal variation). At 12 months, one participant receiving 300 000 IU was mildly deficient (25-OHD 49 nmol/l), whereas five out of six (83%) in the placebo and four out of seven participants (57%) in the 150 000 IU group remained deficient. There were no adverse events. Compliance was high. This suggests that 300 000 IU vitamin D3 orally 6-monthly may safely and effectively correct vitamin D deficiency in adolescents.
History
Publication title
European Journal of Clinical NutritionVolume
66Pagination
530-532ISSN
1476-5640Department/School
Menzies Institute for Medical ResearchPublisher
Nature Publishing GroupPlace of publication
United KingdomRights statement
© 2011 Nature Publishing GroupRepository Status
- Restricted