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Intermittent high-dose vitamin D corrects vitamin D deficiency in adolescents: a pilot study
Citation
Carnes, J and Quinn, S and Nelson, M and Jones, G and Winzenberg, T, Intermittent high-dose vitamin D corrects vitamin D deficiency in adolescents: a pilot study, European Journal of Clinical Nutrition, 66 pp. 530-532. ISSN 1476-5640 (2011) [Refereed Article]
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Copyright Statement
© 2011 Nature Publishing Group
DOI: doi:10.1038/ejcn.2011.204
Abstract
We aimed to assess the safety and efficacy of high-dose intermittent vitamin D supplementation in adolescents. Twenty-two
healthy adolescents with serum 25 hydroxy-vitamin D (25-OHD) of 12.5–50 nmol/l were randomised to receive 300 000 IU or
150 000 IU of vitamin D3, or placebo orally 6-monthly for 1 year. At 12 months, the average vitamin D levels for the 300 000 IU,
150 000 IU and placebo groups were 63.0, 41.1 and 35.8 nmol/l, respectively, (P = 0.004 for difference between 300 000 IU
group and placebo after adjustment for age, sex and seasonal variation). At 12 months, one participant receiving 300 000 IU was
mildly deficient (25-OHD 49 nmol/l), whereas five out of six (83%) in the placebo and four out of seven participants (57%) in the
150 000 IU group remained deficient. There were no adverse events. Compliance was high. This suggests that 300 000 IU
vitamin D3 orally 6-monthly may safely and effectively correct vitamin D deficiency in adolescents.
Item Details
Item Type: | Refereed Article |
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Keywords: | vitamin D; children; clinical trials; osteoporosis |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Clinical sciences |
Research Field: | Rheumatology and arthritis |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Carnes, J (Mr Jonathan Carnes) |
UTAS Author: | Nelson, M (Professor Mark Nelson) |
UTAS Author: | Jones, G (Professor Graeme Jones) |
UTAS Author: | Winzenberg, T (Professor Tania Winzenberg) |
ID Code: | 75744 |
Year Published: | 2011 |
Web of Science® Times Cited: | 16 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2012-02-14 |
Last Modified: | 2017-10-06 |
Downloads: | 1 View Download Statistics |
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